FUNCTIONAL IMPAIRMENT OF MOUSE AND HUMAN DENDRITIC CELLS FOLLOWING SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS): TOWARDS NOVEL DIAGNOSTICS AND TREATMENTS
Grant number: 1163090 | Funding period: 2019 - 2022
Severe infections, trauma or stroke cause Systemic Inflammatory Response Syndrome (SIRS). SIRS patients often succumb to otherwise innocuous infections because SIRS induces a long state of immune suppression. We think an underlying mechanisms is the functional impairment of a critical immune cell type called dendritic cells (DC). The goal of this grant is to develop tools to measure, predict and prevent the formation of these 'paralysed DC' to restore a healthy immune system in SIRS patients.
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Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among ..
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Shengbo Zhang, Hannah D Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J Kueh, Daniel Brown, Wang Cao, Nicolas Jacquelot, Angela D'Amico, Andrew M Lew, Yifan Zhan, Christopher J Tonkin, Jose A Villadangos, Gordon K Smyth, Michael Chopin, Stephen L Nutt
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Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..