ADDRESSING THE MAJOR CHALLENGES IN HIV VACCINE AND CURE RESEARCH
Grant number: 1149990 | Funding period: 2019 - 2023
HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections each year. Despite advances in management of HIV infection with antiretroviral therapy, there is still no cure, no effective vaccine, and several co-infections reduce life expectancy. This program assembles Australia’s leading HIV researchers to use innovative basic and translational science to tackle priority areas in controlling the HIV epidemic.
Related publications (59)
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IM Barber-Axthelm, KM Wragg, R Esterbauer, TH Amarasena, VRB Barber-Axthelm, AK Wheatley, AM Gibbon, SJ Kent, JA Juno
While gaining interest as treatment for cancer and infectious disease, the clinical efficacy of Vγ9Vδ2 T cell-based immunotherapeu..
Predicting the efficacy of variant-modified COVID-19 vaccine boosters.
David S Khoury, Steffen S Docken, Kanta Subbarao, Stephen J Kent, Miles P Davenport, Deborah Cromer
Booster vaccination for the prevention of Coronavirus Disease 2019 (COVID-19) is required to overcome loss of protection due to wa..
Layer-by-Layer Particles Deliver Epigenetic Silencing siRNA to HIV-1 Latent Reservoir Cell Types.
Ewa Czuba-Wojnilowicz, Vera Klemm, Christina Cortez-Jugo, Stuart Turville, Anupriya Aggarwal, Frank Caruso, Anthony D Kelleher, Chantelle L Ahlenstiel
For over two decades, nanomaterials have been employed to facilitate intracellular delivery of small interfering RNA (siRNA), both..
Circulating effector gamma delta T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals
Anouk von Borstel, Thi HO Nguyen, Louise C Rowntree, Thomas M Ashhurst, Lilith F Allen, Lauren J Howson, Natasha E Holmes, Olivia C Smibert, Jason A Trubiano, Claire L Gordon, Allen C Cheng, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Martin S Davey
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a smal..
Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation
Yijiao Qu, Robert De Rose, Chan-Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez-Jugo, Francesca Cavalieri, Frank Caruso
DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A ..
Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection.
David S Khoury, Timothy E Schlub, Deborah Cromer, Megan Steain, Youyi Fong, Peter B Gilbert, Kanta Subbarao, James A Triccas, Stephen J Kent, Miles P Davenport
Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the..
Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4.
Katie Fisher, Timothy E Schlub, Zoe Boyer, Thomas A Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M Hecht, Steven G Deeks, Sharon R Lewin, Sarah Palmer
INTRODUCTION: HIV-1 persists in resting CD4+ T-cells despite antiretroviral therapy (ART). Determining the cell surface markers th..
Memory CD4( ) T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency
Thomas A Rasmussen, Jennifer M Zerbato, Ajantha Rhodes, Carolin Tumpach, Ashanti Dantanarayana, James H McMahon, Jillian SY Lau, J Judy Chang, Celine Gubser, Wendy Brown, Rebecca Hoh, Melissa Krone, Rachel Pascoe, Chris Y Chiu, Michael Bramhall, Hyun Jae Lee, Ashraful Haque, Remi Fromentin, Nicolas Chomont, Jeffrey Milush
Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4+ T cell activation and may prom..
Phenotypic and functional characteristics of highly differentiated CD57( )NKG2C( ) NK cells in HIV-1-infected individuals
Anne B Kristensen, Kathleen Wragg, Hillary Vanderven, Wen Shi Lee, Julie Silvers, Helen E Kent, Michael D Grant, Anthony D Kelleher, Jennifer A Juno, Stephen J Kent, Matthew S Parsons
Natural killer (NK) cells are important anti-viral effector cells. The function and phenotype of the NK cells that constitute an i..
Markers of Immune Activation and Inflammation Are Associated with Higher Levels of Genetically-Intact HIV in HIV-HBV Co-Infected Individuals
Xiao Qian Wang, Jennifer M Zerbato, Anchalee Avihingsanon, Katie Fisher, Timothy Schlub, Ajantha Rhodes, Jennifer Audsley, Kasha P Singh, Wei Zhao, Sharon R Lewin, Sarah Palmer
Co-infection with hepatitis B (HBV) and human immunodeficiency virus (HIV) increases overall and liver-related mortality. In order..
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy W Chung
Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain ..
SARS-CoV-2-specific T cell memory with common TCR alpha beta motifs is established in unvaccinated children who seroconvert after infection
Louise C Rowntree, Thi HO Nguyen, Lukasz Kedzierski, Melanie R Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F Allen, E Bridie Clemens, Brendon Chua, Hayley A McQuilten, Anastasia A Minervina, Mikhail Pogorelyy, Priyanka Chaurasia, Hyon-Xhi Tan, Adam K Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E Kaitlynn Allen, Sabrina Sonda
As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains la..
The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants
Marios Koutsakos, Wen Shi Lee, Arnold Reynaldi, Hyon-Xhi Tan, Grace Gare, Paul Kinsella, Kwee Chin Liew, George Taiaroa, Deborah A Williamson, Helen E Kent, Eva Stadler, Deborah Cromer, David S Khoury, Adam K Wheatley, Jennifer A Juno, Miles P Davenport, Stephen J Kent
Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in breakthrough infections, likely reflectin..
Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine
Yi Ju, Wen Shi Lee, Emily H Pilkington, Hannah G Kelly, Shiyao Li, Kevin J Selva, Kathleen M Wragg, Kanta Subbarao, Thi HO Nguyen, Louise C Rowntree, Lilith F Allen, Katherine Bond, Deborah A Williamson, Nghia P Truong, Magdalena Plebanski, Katherine Kedzierska, Siddhartha Mahanty, Amy W Chung, Frank Caruso, Adam K Wheatley
Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) m..
Cutting Edge: SARS-CoV-2 Infection Induces Robust Germinal Center Activity in the Human Tonsil
Hyon-Xhi Tan, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Benjamin J Dixon, Jillian SY Lau, Katie L Flanagan, Carolien E van de Sandt, Katherine Kedzierska, James H McMahon, Adam K Wheatley, Jennifer A Juno, Stephen J Kent
Understanding the generation of immunity to SARS-CoV-2 in lymphoid tissues draining the site of infection has implications for imm..
Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?
Stephen J Kent, David S Khoury, Arnold Reynold, Jennifer A Juno, Adam K Wheatley, Eva Stadler, E John Wherry, James Triccas, Sarah C Sasson, Deborah Cromer, Miles P Davenport
The rapid development of multiple vaccines providing strong protection from severe acute respiratory syndrome coronavirus 2 (SARS-..
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4( ) T cell memory
Kathleen M Wragg, Wen Shi Lee, Marios Koutsakos, Hyon-Xhi Tan, Thakshila Amarasena, Arnold Reynaldi, Grace Gare, Penny Konstandopoulos, Kirsty R Field, Robyn Esterbauer, Helen E Kent, Miles P Davenport, Adam K Wheatley, Stephen J Kent, Jennifer A Juno
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit CD4+ T cell responses to the spike p..
Balancing Statistical Power and Risk in HIV Cure Clinical Trial Design
Jillian SY Lau, Deborah Cromer, Mykola Pinkevych, Sharon R Lewin, Thomas A Rasmussen, James H McMahon, Miles P Davenport
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Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor
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Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected..
At Least Three Doses of Leading Vaccines Essential for Neutralisation of SARS-CoV-2 Omicron Variant.
Nagendrakumar B Singanallur, Petrus Jansen van Vuren, Alexander J McAuley, Matthew P Bruce, Michael J Kuiper, Stella M Gwini, Shane Riddell, Sarah Goldie, Trevor W Drew, Kim R Blasdell, Mary Tachedjian, Shruthi Mangalaganesh, Simran Chahal, Leon Caly, Julian D Druce, Jennifer A Juno, Stephen J Kent, Adam K Wheatley, Seshadri S Vasan
Plasma samples taken at different time points from donors who received either AstraZeneca (Vaxzevria) or Pfizer (Comirnaty) or Mod..
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
Chansavath Phetsouphanh, David Darley, Daniel B Wilson, Annett Howe, C Mee Ling Munier, Sheila K Patel, Jennifer A Juno, Louise M Burrell, Stephen J Kent, Gregory J Dore, Anthony D Kelleher, Gail Matthews
A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COV..
Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy
Chris Y Chiu, Judy J Chang, Ashanti Dantanarayana, Ajantha Solomon, Vanessa A Evans, Rachel Pascoe, Celine Gubser, Lydie Trautman, Remi Fromentin, Nicolas Chomont, James H McMahon, Paul U Cameron, Thomas A Rasmussen, Sharon R Lewin
In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune che..
Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis
Deborah Cromer, Megan Steain, Arnold Reynaldi, Timothy E Schlub, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, James A Triccas, David S Khoury, Miles P Davenport
BACKGROUND: Several SARS-CoV-2 variants of concern have been identified that partly escape serum neutralisation elicited by curren..
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
Steven G Deeks, Nancie Archin, Paula Cannon, Simon Collins, R Brad Jones, Marein AWP de Jong, Olivier Lambotte, Rosanne Lamplough, Thumbi Ndung'u, Jeremy Sugarman, Caroline T Tiemessen, Linos Vandekerckhove, Sharon R Lewin
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cur..
Cell-Associated Human Immunodeficiency Virus (HIV) Ribonucleic Acid Has a Circadian Cycle in Males With HIV on Antiretroviral Therapy
Jared Stern, Ajantha Solomon, Ashanti Dantanarayana, Rachel Pascoe, Arnold Reynaldi, Miles P Davenport, Jeffrey Milush, Steven G Deeks, Wendy Hartogensis, Frederick M Hecht, Leslie Cockerham, Michael Roche, Sharon R Lewin
BACKGROUND: Circadian transcription factors that regulate cell-autonomous circadian clocks can also increase human immunodeficienc..
Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians
Luca Hensen, Thi HO Nguyen, Louise C Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L Harland, Maria Auladell, Carolien E van de Sandt, Anngie Everitt, Cath Blacker, Damian A Oyong, Jessica R Loughland, Jessica R Webb, Bruce D Wines, P Mark Hogarth, Katie L Flanagan, Magdalena Plebanski, Adam Wheatley
Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigen..
Impact of Anti-PD-1 and Anti-CTLA-4 on the Human Immunodeficiency Virus (HIV) Reservoir in People Living With HIV With Cancer on Antiretroviral Therapy: The AIDS Malignancy Consortium 095 Study
Thomas A Rasmussen, Lakshmi Rajdev, Ajantha Rhodes, Ashanti Dantanarayana, Surekha Tennakoon, Socheata Chea, Tim Spelman, Shelly Lensing, Rachel Rutishauser, Sonia Bakkour, Michael Busch, Janet D Siliciano, Robert F Siliciano, Mark H Einstein, Dirk P Dittmer, Elizabeth Chiao, Steven G Deeks, Christine Durand, Sharon R Lewin
BACKGROUND: Antibodies to programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) may perturb huma..
Coformulation with Tattoo Ink for Immunological Assessment of Vaccine Immunogenicity in the Draining Lymph Node
Isaac M Barber-Axthelm, Hannah G Kelly, Robyn Esterbauer, Kathleen M Wragg, Anne M Gibbon, Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Hyon-Xhi Tan, Jennifer A Juno
Characterization of germinal center B and T cell responses yields critical insights into vaccine immunogenicity. Nonhuman primates..
SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph
Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..
A Focus on "Bio" in Bio-Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions
Christina Cortez-Jugo, Ewa Czuba-Wojnilowicz, Abigail Tan, Frank Caruso
Bio-nanoscience research encompasses studies on the interactions of nanomaterials with biological structures or what is commonly r..
Decay of Fc-dependent antibody functions after mild to moderate COVID-19
Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent
The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
David S Khoury, Deborah Cromer, Arnold Reynaldi, Timothy E Schlub, Adam K Wheatley, Jennifer A Juno, Kanta Subbarao, Stephen J Kent, James A Triccas, Miles P Davenport
Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the fut..
CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..
Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences
Sheila K Patel, Jennifer A Juno, Wen Shi Lee, Kathleen M Wragg, P Mark Hogarth, Stephen J Kent, Louise M Burrell
Plasma ACE2 activity is persistently elevated in patients after COVID-19 infection. Larger studies are needed to determine if this..
Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection
Deborah Cromer, Jennifer A Juno, David Khoury, Arnold Reynaldi, Adam K Wheatley, Stephen J Kent, Miles P Davenport
Immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is central to long-term control of the current ..
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..
Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
Tan Hyon-Xhi, Jennifer A Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G Kelly, Kathleen M Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L Mordant, Kanta Subbarao, Stephen J Kent, Adam K Wheatley
SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..
Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency
Jennifer M Zerbato, Georges Khoury, Wei Zhao, Matthew J Gartner, Rachel D Pascoe, Ajantha Rhodes, Ashanti Dantanarayana, Megan Gooey, Jenny Anderson, Peter Bacchetti, Steven G Deeks, James McMahon, Michael Roche, Thomas A Rasmussen, Damian FJ Purcell, Sharon R Lewin
BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretro..
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung
The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..
In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design
Paula M Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R Lewin, Christina Cortez-Jugo, Frank Caruso
T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, a..
Screening and development of monoclonal antibodies for identification of ferret T follicular helper cells
Wenbo Jiang, Julius Wong, Hyon-Xhi Tan, Hannah G Kelly, Paul G Whitney, Ian Barr, Daniel S Layton, Stephen J Kent, Adam K Wheatley, Jennifer A Juno
The ferret is a key animal model for investigating the pathogenicity and transmissibility of important human viruses, and for the ..
Adaptive immunity to human coronaviruses is widespread but low in magnitude
Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Christina Nelson, Robyn Esterbauer, Hannah G Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Michael Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, Laura K Mackay, Claire L Gordon, Adam K Wheatley, Stephen J Kent
OBJECTIVES: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV i..
Tear antibodies to SARS-CoV-2: implications for transmission
Kevin J Selva, Samantha K Davis, Ebene R Haycroft, Wen Shi Lee, Ester Lopez, Arnold Reynaldi, Miles P Davenport, Helen E Kent, Jennifer A Juno, Amy W Chung, Stephen J Kent
OBJECTIVES: SARS-CoV-2 can be transmitted by aerosols, and the ocular surface may be an important route of transmission. Little is..
Aggregation by peptide conjugation rescues poor immunogenicity of the HA stem
Wenbo Jiang, Emily H Pilkington, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, Stephen J Kent
Influenza virus infection is a global public health threat. Current seasonal influenza vaccines are efficacious only when vaccine ..
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir
Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Feng Hsiao, Tongcui Ma, Vincent Morcilla, Ashley Lee, Sushama Telwatte, Reuben Thomas, Whitney Tamaki, Benjamin Wheeler, Rebecca Hoh, Ma Somsouk, Poonam Vohra, Jeffrey Milush, Katherine Sholtis James, Nancie M Archin, Peter W Hunt, Steven G Deeks
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be phenotyped directly, the features of the..
Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype
Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen
An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..
Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection
Kasha P Singh, Jennifer M Zerbato, Wei Zhao, Sabine Braat, Claire Deleage, G Surekha Tennakoon, Hugh Mason, Ashanti Dantanarayana, Ajantha Rhodes, Jake W Rhodes, Joe Torresi, Andrew N Harman, Peter A Revill, Megan Crane, Jacob D Estes, Anchalee Avihingsanon, Sharon R Lewin, Jennifer Audsley
In HIV-hepatitis B virus (HBV) co-infection, adverse liver outcomes including liver fibrosis occur at higher frequency than in HBV..
Understanding the Role of Mucosal-Associated Invariant T-Cells in Non-human Primate Models of HIV Infection
Isaac M Barber-Axthelm, Stephen J Kent, Jennifer A Juno
Chronic HIV infection causes systemic immune activation and dysregulation, resulting in the impairment of most T-cell subsets incl..
Longitudinal analysis of subtype C envelope tropism for memory CD4( )T cell subsets over the first 3 years of untreated HIV-1 infection
Matthew J Gartner, Paul R Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J Judy Chang, Thomas A Angelovich, Paula Ellenberg, Annemarie E Laumaea, Molati Nonyane, Penny L Moore, Sharon R Lewin, Melissa J Churchill, Jacqueline K Flynn, Michael Roche
BACKGROUND: HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of ent..
Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation
Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso
There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.
Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..