ADDRESSING THE MAJOR CHALLENGES IN HIV VACCINE AND CURE RESEARCH

Phenotypic and functional characterization of pharmacologically expanded Vγ9Vδ2 T cells in pigtail macaques

IM Barber-Axthelm, KM Wragg, R Esterbauer, TH Amarasena, VRB Barber-Axthelm, AK Wheatley, AM Gibbon, SJ Kent, JA Juno

2023-03-17

While gaining interest as treatment for cancer and infectious disease, the clinical efficacy of Vγ9Vδ2 T cell-based immunotherapeu..

Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan‐Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez‐Jugo, Francesca Cavalieri, Frank Caruso

2023-03-13

Predicting the efficacy of variant-modified COVID-19 vaccine boosters.

David S Khoury, Steffen S Docken, Kanta Subbarao, Stephen J Kent, Miles P Davenport, Deborah Cromer

2023-03-02

Booster vaccination for the prevention of Coronavirus Disease 2019 (COVID-19) is required to overcome loss of protection due to wa..

Layer-by-Layer Particles Deliver Epigenetic Silencing siRNA to HIV-1 Latent Reservoir Cell Types.

Ewa Czuba-Wojnilowicz, Vera Klemm, Christina Cortez-Jugo, Stuart Turville, Anupriya Aggarwal, Frank Caruso, Anthony D Kelleher, Chantelle L Ahlenstiel

2023-02-27

For over two decades, nanomaterials have been employed to facilitate intracellular delivery of small interfering RNA (siRNA), both..

Circulating effector gamma delta T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals

Anouk von Borstel, Thi HO Nguyen, Louise C Rowntree, Thomas M Ashhurst, Lilith F Allen, Lauren J Howson, Natasha E Holmes, Olivia C Smibert, Jason A Trubiano, Claire L Gordon, Allen C Cheng, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Martin S Davey

2023-02-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a smal..

Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan-Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez-Jugo, Francesca Cavalieri, Frank Caruso

2023-02-10

DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A ..

Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection.

David S Khoury, Timothy E Schlub, Deborah Cromer, Megan Steain, Youyi Fong, Peter B Gilbert, Kanta Subbarao, James A Triccas, Stephen J Kent, Miles P Davenport

2023-02-01

Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the..

Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4.

Katie Fisher, Timothy E Schlub, Zoe Boyer, Thomas A Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M Hecht, Steven G Deeks, Sharon R Lewin, Sarah Palmer

2023-01-26

INTRODUCTION: HIV-1 persists in resting CD4+ T-cells despite antiretroviral therapy (ART). Determining the cell surface markers th..

On predicting heterogeneity in nanoparticle dosage

Celia V Dowling, Paula M Cevaal, Matthew Faria, Stuart T Johnston

2022-11-14

Nanoparticles are increasingly employed as a vehicle for the targeted delivery of therapeutics to specific cell types. However, mu..

Memory CD4( ) T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency

Thomas A Rasmussen, Jennifer M Zerbato, Ajantha Rhodes, Carolin Tumpach, Ashanti Dantanarayana, James H McMahon, Jillian SY Lau, J Judy Chang, Celine Gubser, Wendy Brown, Rebecca Hoh, Melissa Krone, Rachel Pascoe, Chris Y Chiu, Michael Bramhall, Hyun Jae Lee, Ashraful Haque, Remi Fromentin, Nicolas Chomont, Jeffrey Milush

2022-10-18

Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4+ T cell activation and may prom..

mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

2022-09-20

Messenger RNA (mRNA) holds great potential as a disease-modifying treatment for a wide array of monogenic disorders. Niemann-Pick ..

Phenotypic and functional characteristics of highly differentiated CD57( )NKG2C( ) NK cells in HIV-1-infected individuals

Anne B Kristensen, Kathleen Wragg, Hillary Vanderven, Wen Shi Lee, Julie Silvers, Helen E Kent, Michael D Grant, Anthony D Kelleher, Jennifer A Juno, Stephen J Kent, Matthew S Parsons

2022-09-02

Natural killer (NK) cells are important anti-viral effector cells. The function and phenotype of the NK cells that constitute an i..

Markers of Immune Activation and Inflammation Are Associated with Higher Levels of Genetically-Intact HIV in HIV-HBV Co-Infected Individuals

Xiao Qian Wang, Jennifer M Zerbato, Anchalee Avihingsanon, Katie Fisher, Timothy Schlub, Ajantha Rhodes, Jennifer Audsley, Kasha P Singh, Wei Zhao, Sharon R Lewin, Sarah Palmer

2022-08-02

Co-infection with hepatitis B (HBV) and human immunodeficiency virus (HIV) increases overall and liver-related mortality. In order..

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy W Chung

2022-07-28

Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain ..

SARS-CoV-2-specific T cell memory with common TCR alpha beta motifs is established in unvaccinated children who seroconvert after infection

Louise C Rowntree, Thi HO Nguyen, Lukasz Kedzierski, Melanie R Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F Allen, E Bridie Clemens, Brendon Chua, Hayley A McQuilten, Anastasia A Minervina, Mikhail Pogorelyy, Priyanka Chaurasia, Hyon-Xhi Tan, Adam K Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E Kaitlynn Allen, Sabrina Sonda

2022-07-12

As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains la..

The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants

Marios Koutsakos, Wen Shi Lee, Arnold Reynaldi, Hyon-Xhi Tan, Grace Gare, Paul Kinsella, Kwee Chin Liew, George Taiaroa, Deborah A Williamson, Helen E Kent, Eva Stadler, Deborah Cromer, David S Khoury, Adam K Wheatley, Jennifer A Juno, Miles P Davenport, Stephen J Kent

2022-07-12

Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in breakthrough infections, likely reflectin..

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Yi Ju, Wen Shi Lee, Emily H Pilkington, Hannah G Kelly, Shiyao Li, Kevin J Selva, Kathleen M Wragg, Kanta Subbarao, Thi HO Nguyen, Louise C Rowntree, Lilith F Allen, Katherine Bond, Deborah A Williamson, Nghia P Truong, Magdalena Plebanski, Katherine Kedzierska, Siddhartha Mahanty, Amy W Chung, Frank Caruso, Adam K Wheatley

2022-06-27

Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) m..

Cutting Edge: SARS-CoV-2 Infection Induces Robust Germinal Center Activity in the Human Tonsil

Hyon-Xhi Tan, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Benjamin J Dixon, Jillian SY Lau, Katie L Flanagan, Carolien E van de Sandt, Katherine Kedzierska, James H McMahon, Adam K Wheatley, Jennifer A Juno, Stephen J Kent

2022-05-15

Understanding the generation of immunity to SARS-CoV-2 in lymphoid tissues draining the site of infection has implications for imm..

Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?

Stephen J Kent, David S Khoury, Arnold Reynold, Jennifer A Juno, Adam K Wheatley, Eva Stadler, E John Wherry, James Triccas, Sarah C Sasson, Deborah Cromer, Miles P Davenport

2022-04-28

The rapid development of multiple vaccines providing strong protection from severe acute respiratory syndrome coronavirus 2 (SARS-..

Establishment and recall of SARS-CoV-2 spike epitope-specific CD4( ) T cell memory

Kathleen M Wragg, Wen Shi Lee, Marios Koutsakos, Hyon-Xhi Tan, Thakshila Amarasena, Arnold Reynaldi, Grace Gare, Penny Konstandopoulos, Kirsty R Field, Robyn Esterbauer, Helen E Kent, Miles P Davenport, Adam K Wheatley, Stephen J Kent, Jennifer A Juno

2022-03-21

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit CD4+ T cell responses to the spike p..

Balancing Statistical Power and Risk in HIV Cure Clinical Trial Design

Jillian SY Lau, Deborah Cromer, Mykola Pinkevych, Sharon R Lewin, Thomas A Rasmussen, James H McMahon, Miles P Davenport

2022-02-01

BACKGROUND: Analytical treatment interruptions (ATI) are pauses of antiretroviral therapy (ART) in the context of human immunodefi..

Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor

Alessia Amodio, Marco Cassani, Liviana Mummolo, Christina Cortez-Jugo, Sukhvir Kaur Bhangu, Jori Symons, Chantelle L Ahlenstiel, Giancarlo Forte, Francesco Ricci, Anthony D Kelleher, Sharon R Lewin, Francesca Cavalieri, Frank Caruso

2022-01-31

Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected..

At Least Three Doses of Leading Vaccines Essential for Neutralisation of SARS-CoV-2 Omicron Variant.

Nagendrakumar B Singanallur, Petrus Jansen van Vuren, Alexander J McAuley, Matthew P Bruce, Michael J Kuiper, Stella M Gwini, Shane Riddell, Sarah Goldie, Trevor W Drew, Kim R Blasdell, Mary Tachedjian, Shruthi Mangalaganesh, Simran Chahal, Leon Caly, Julian D Druce, Jennifer A Juno, Stephen J Kent, Adam K Wheatley, Seshadri S Vasan

2022-01-17

Plasma samples taken at different time points from donors who received either AstraZeneca (Vaxzevria) or Pfizer (Comirnaty) or Mod..

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

Chansavath Phetsouphanh, David Darley, Daniel B Wilson, Annett Howe, C Mee Ling Munier, Sheila K Patel, Jennifer A Juno, Louise M Burrell, Stephen J Kent, Gregory J Dore, Anthony D Kelleher, Gail Matthews

2022-01-13

A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COV..

Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy

Chris Y Chiu, Judy J Chang, Ashanti Dantanarayana, Ajantha Solomon, Vanessa A Evans, Rachel Pascoe, Celine Gubser, Lydie Trautman, Remi Fromentin, Nicolas Chomont, James H McMahon, Paul U Cameron, Thomas A Rasmussen, Sharon R Lewin

2022-01-01

In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune che..

Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis

Deborah Cromer, Megan Steain, Arnold Reynaldi, Timothy E Schlub, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, James A Triccas, David S Khoury, Miles P Davenport

2022-01-01

BACKGROUND: Several SARS-CoV-2 variants of concern have been identified that partly escape serum neutralisation elicited by curren..

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Steven G Deeks, Nancie Archin, Paula Cannon, Simon Collins, R Brad Jones, Marein AWP de Jong, Olivier Lambotte, Rosanne Lamplough, Thumbi Ndung'u, Jeremy Sugarman, Caroline T Tiemessen, Linos Vandekerckhove, Sharon R Lewin

2021-12-01

Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cur..

Cell-Associated Human Immunodeficiency Virus (HIV) Ribonucleic Acid Has a Circadian Cycle in Males With HIV on Antiretroviral Therapy

Jared Stern, Ajantha Solomon, Ashanti Dantanarayana, Rachel Pascoe, Arnold Reynaldi, Miles P Davenport, Jeffrey Milush, Steven G Deeks, Wendy Hartogensis, Frederick M Hecht, Leslie Cockerham, Michael Roche, Sharon R Lewin

2021-11-24

BACKGROUND: Circadian transcription factors that regulate cell-autonomous circadian clocks can also increase human immunodeficienc..

Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians

Luca Hensen, Thi HO Nguyen, Louise C Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L Harland, Maria Auladell, Carolien E van de Sandt, Anngie Everitt, Cath Blacker, Damian A Oyong, Jessica R Loughland, Jessica R Webb, Bruce D Wines, P Mark Hogarth, Katie L Flanagan, Magdalena Plebanski, Adam Wheatley

2021-10-12

Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigen..

Impact of Anti-PD-1 and Anti-CTLA-4 on the Human Immunodeficiency Virus (HIV) Reservoir in People Living With HIV With Cancer on Antiretroviral Therapy: The AIDS Malignancy Consortium 095 Study

Thomas A Rasmussen, Lakshmi Rajdev, Ajantha Rhodes, Ashanti Dantanarayana, Surekha Tennakoon, Socheata Chea, Tim Spelman, Shelly Lensing, Rachel Rutishauser, Sonia Bakkour, Michael Busch, Janet D Siliciano, Robert F Siliciano, Mark H Einstein, Dirk P Dittmer, Elizabeth Chiao, Steven G Deeks, Christine Durand, Sharon R Lewin

2021-10-01

BACKGROUND: Antibodies to programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) may perturb huma..

Coformulation with Tattoo Ink for Immunological Assessment of Vaccine Immunogenicity in the Draining Lymph Node

Isaac M Barber-Axthelm, Hannah G Kelly, Robyn Esterbauer, Kathleen M Wragg, Anne M Gibbon, Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Hyon-Xhi Tan, Jennifer A Juno

2021-07-15

Characterization of germinal center B and T cell responses yields critical insights into vaccine immunogenicity. Nonhuman primates..

SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen

2021-06-30

In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..

A Focus on "Bio" in Bio-Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions

Christina Cortez-Jugo, Ewa Czuba-Wojnilowicz, Abigail Tan, Frank Caruso

2021-06-25

Bio-nanoscience research encompasses studies on the interactions of nanomaterials with biological structures or what is commonly r..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent

2021-06-15

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S Khoury, Deborah Cromer, Arnold Reynaldi, Timothy E Schlub, Adam K Wheatley, Jennifer A Juno, Kanta Subbarao, Stephen J Kent, James A Triccas, Miles P Davenport

2021-05-17

Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the fut..

CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud

2021-05-11

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

Sheila K Patel, Jennifer A Juno, Wen Shi Lee, Kathleen M Wragg, P Mark Hogarth, Stephen J Kent, Louise M Burrell

2021-05-01

Plasma ACE2 activity is persistently elevated in patients after COVID-19 infection. Larger studies are needed to determine if this..

Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection

Deborah Cromer, Jennifer A Juno, David Khoury, Arnold Reynaldi, Adam K Wheatley, Stephen J Kent, Miles P Davenport

2021-04-29

Immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is central to long-term control of the current ..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi

2021-04-01

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley

2021-03-16

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Tan Hyon-Xhi, Jennifer A Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G Kelly, Kathleen M Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L Mordant, Kanta Subbarao, Stephen J Kent, Adam K Wheatley

2021-03-03

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

Jennifer M Zerbato, Georges Khoury, Wei Zhao, Matthew J Gartner, Rachel D Pascoe, Ajantha Rhodes, Ashanti Dantanarayana, Megan Gooey, Jenny Anderson, Peter Bacchetti, Steven G Deeks, James McMahon, Michael Roche, Thomas A Rasmussen, Damian FJ Purcell, Sharon R Lewin

2021-02-26

BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretro..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung

2021-02-19

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

Paula M Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R Lewin, Christina Cortez-Jugo, Frank Caruso

2021-02-18

T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, a..

Screening and development of monoclonal antibodies for identification of ferret T follicular helper cells

Wenbo Jiang, Julius Wong, Hyon-Xhi Tan, Hannah G Kelly, Paul G Whitney, Ian Barr, Daniel S Layton, Stephen J Kent, Adam K Wheatley, Jennifer A Juno

2021-01-21

The ferret is a key animal model for investigating the pathogenicity and transmissibility of important human viruses, and for the ..

Adaptive immunity to human coronaviruses is widespread but low in magnitude

Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Christina Nelson, Robyn Esterbauer, Hannah G Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Michael Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, Laura K Mackay, Claire L Gordon, Adam K Wheatley, Stephen J Kent

2021-01-01

OBJECTIVES: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV i..

Tear antibodies to SARS-CoV-2: implications for transmission

Kevin J Selva, Samantha K Davis, Ebene R Haycroft, Wen Shi Lee, Ester Lopez, Arnold Reynaldi, Miles P Davenport, Helen E Kent, Jennifer A Juno, Amy W Chung, Stephen J Kent

2021-01-01

OBJECTIVES: SARS-CoV-2 can be transmitted by aerosols, and the ocular surface may be an important route of transmission. Little is..

Aggregation by peptide conjugation rescues poor immunogenicity of the HA stem

Wenbo Jiang, Emily H Pilkington, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, Stephen J Kent

2020-11-02

Influenza virus infection is a global public health threat. Current seasonal influenza vaccines are efficacious only when vaccine ..

Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Feng Hsiao, Tongcui Ma, Vincent Morcilla, Ashley Lee, Sushama Telwatte, Reuben Thomas, Whitney Tamaki, Benjamin Wheeler, Rebecca Hoh, Ma Somsouk, Poonam Vohra, Jeffrey Milush, Katherine Sholtis James, Nancie M Archin, Peter W Hunt, Steven G Deeks

2020-09-29

The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be phenotyped directly, the features of the..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen

2020-09-29

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Brandon J DeKosky

2020-09-09

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through..

Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection

Kasha P Singh, Jennifer M Zerbato, Wei Zhao, Sabine Braat, Claire Deleage, G Surekha Tennakoon, Hugh Mason, Ashanti Dantanarayana, Ajantha Rhodes, Jake W Rhodes, Joe Torresi, Andrew N Harman, Peter A Revill, Megan Crane, Jacob D Estes, Anchalee Avihingsanon, Sharon R Lewin, Jennifer Audsley

2020-09-01

In HIV-hepatitis B virus (HBV) co-infection, adverse liver outcomes including liver fibrosis occur at higher frequency than in HBV..

Understanding the Role of Mucosal-Associated Invariant T-Cells in Non-human Primate Models of HIV Infection

Isaac M Barber-Axthelm, Stephen J Kent, Jennifer A Juno

2020-08-18

Chronic HIV infection causes systemic immune activation and dysregulation, resulting in the impairment of most T-cell subsets incl..

Block and Lock HIV Cure Strategies to Control the Latent Reservoir

Chantelle L Ahlenstiel, Geoff Symonds, Stephen J Kent, Anthony D Kelleher

2020-08-14

The HIV latent reservoir represents the major challenge to cure development. Residing in resting CD4+ T cells and myeloid cells at..

Longitudinal analysis of subtype C envelope tropism for memory CD4( )T cell subsets over the first 3 years of untreated HIV-1 infection

Matthew J Gartner, Paul R Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J Judy Chang, Thomas A Angelovich, Paula Ellenberg, Annemarie E Laumaea, Molati Nonyane, Penny L Moore, Sharon R Lewin, Melissa J Churchill, Jacqueline K Flynn, Michael Roche

2020-08-06

BACKGROUND: HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of ent..

Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation

Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso

2020-08-06

There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

2020-07-13

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

Sequencing B cell receptors from ferrets (Mustela putorius furo)

Julius Wong, Celeste M Tai, Aeron C Hurt, Hyon-Xhi Tan, Stephen J Kent, Adam K Wheatley

2020-05-29

The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunolo..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..