ADDRESSING THE MAJOR CHALLENGES IN HIV VACCINE AND CURE RESEARCH

SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen

2021-06-30

In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..

A Focus on "Bio" in Bio-Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions

Christina Cortez-Jugo, Ewa Czuba-Wojnilowicz, Abigail Tan, Frank Caruso

2021-06-25

Bio-nanoscience research encompasses studies on the interactions of nanomaterials with biological structures or what is commonly r..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent

2021-06-15

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S Khoury, Deborah Cromer, Arnold Reynaldi, Timothy E Schlub, Adam K Wheatley, Jennifer A Juno, Kanta Subbarao, Stephen J Kent, James A Triccas, Miles P Davenport

2021-05-17

Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the fut..

CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud

2021-05-11

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

Sheila K Patel, Jennifer A Juno, Wen Shi Lee, Kathleen M Wragg, P Mark Hogarth, Stephen J Kent, Louise M Burrell

2021-05-01

Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection

Deborah Cromer, Jennifer A Juno, David Khoury, Arnold Reynaldi, Adam K Wheatley, Stephen J Kent, Miles P Davenport

2021-04-29

Immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is central to long-term control of the current ..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi

2021-04-01

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

Paula M Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R Lewin, Christina Cortez-Jugo, Frank Caruso

2021-03-23

T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, a..

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley

2021-03-16

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Tan Hyon-Xhi, Jennifer A Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G Kelly, Kathleen M Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L Mordant, Kanta Subbarao, Stephen J Kent, Adam K Wheatley

2021-03-03

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..

Impact of anti-PD-1 and anti-CTLA-4 on the HIV reservoir in people living with HIV with cancer on antiretroviral therapy: The AIDS Malignancy Consortium-095 study.

Thomas A Rasmussen, Lakshmi Rajdev, Ajantha Rhodes, Ashanti Dantanarayana, Surekha Tennakoon, Socheata Chea, Tim Spelman, Shelly Lensing, Rachel Rutishauser, Sonia Bakkour, Michael Busch, Janet D Siliciano, Robert F Siliciano, Mark H Einstein, Dirk P Dittmer, Elizabeth Chiao, Steven Deeks, Christine Durand, Sharon R Lewin

2021-03-02

BACKGROUND: Antibodies to PD-1 and CTLA-4 may perturb HIV persistence during antiretroviral therapy (ART) by reversing HIV-latency..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung

2021-02-19

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

Adaptive immunity to human coronaviruses is widespread but low in magnitude

Hyon-Xhi Tan, Wen Shi Lee, Kathleen Wragg, Christina Nelson, Robyn Esterbauer, Hannah Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Lindsay Grayson, Helen Opdam, Rohit D’Costa, Angela Vago, Laura Mackay, Claire Gordon, Adam Wheatley, Stephen Kent

2021-01-26

Endemic human coronaviruses (hCoV) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiqui..

Screening and development of monoclonal antibodies for identification of ferret T follicular helper cells

Wenbo Jiang, Julius Wong, Hyon-Xhi Tan, Hannah G Kelly, Paul G Whitney, Ian Barr, Daniel S Layton, Stephen J Kent, Adam K Wheatley, Jennifer A Juno

2021-01-21

The ferret is a key animal model for investigating the pathogenicity and transmissibility of important human viruses, and for the ..

Adaptive immunity to human coronaviruses is widespread but low in magnitude

Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Christina Nelson, Robyn Esterbauer, Hannah G Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Michael Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, Laura K Mackay, Claire L Gordon, Adam K Wheatley, Stephen J Kent

2021-01-01

Objectives: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV i..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha Davis, Bruce Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah Kelly, Ebene Haycroft, Hyon-Xhi Tan, Jennifer Juno, Adam Wheatley, Mark Hogarth, Deborah Cromer, Miles Davenport, Amy Chung, Stephen Kent

2020-12-14

The capacity of antibodies to engage with innate and adaptive immune cells via the Fc region is important in preventing and contro..

Aggregation by peptide conjugation rescues poor immunogenicity of the HA stem

Wenbo Jiang, Emily H Pilkington, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, Stephen J Kent

2020-11-02

Influenza virus infection is a global public health threat. Current seasonal influenza vaccines are efficacious only when vaccine ..

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

Sheila Patel, Jennifer Juno, Wen Shi Lee, Kathleen Wragg, Mark Hogarth, Stephen Kent, Louise Burrell

2020-10-08

COVID-19 causes persistent endothelial inflammation, lung and cardiovascular complications. SARS-CoV-2 utilises the catalytic site..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen

2020-09-29

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Evolution of immunity to SARS-CoV-2

Adam Wheatley, Jennifer Juno, Jing Wang, Kevin Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen Wragg, Hannah Kelly, Robyn Esterbauer, Samantha Davis, Helen Kent, Francesca Mordant, Timothy Schlub, David Gordon, David Khoury, Kanta Subbarao, Deborah Cromer, Tom Gordon, Amy Chung

2020-09-10

The durability of infection-induced SARS-CoV-2 immunity has major implications for public health mitigation and vaccine developmen..

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Brandon J DeKosky

2020-09-09

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through..

Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques

Hyon-Xhi Tan, Jennifer Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah Kelly, Kathleen Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca Mordant, Kanta Subbarao, Stephen Kent, Adam Wheatley

2020-09-02

<h4>Summary</h4> SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralis..

Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection

Kasha P Singh, Jennifer M Zerbato, Wei Zhao, Sabine Braat, Claire Deleage, G Surekha Tennakoon, Hugh Mason, Ashanti Dantanarayana, Ajantha Rhodes, Jake W Rhodes, Joe Torresi, Andrew N Harman, Peter A Revill, Megan Crane, Jacob D Estes, Anchalee Avihingsanon, Sharon R Lewin, Jennifer Audsley

2020-09-01

In HIV-hepatitis B virus (HBV) co-infection, adverse liver outcomes including liver fibrosis occur at higher frequency than in HBV..

Coformulation with tattoo ink for immunological assessment of vaccine immunogenicity in the draining lymph node

Isaac Barber-Axthelm, Hannah Kelly, Robyn Esterbauer, Kathleen Wragg, Anne Gibbon, Wen Shi Lee, Adam Wheatley, Stephen Kent, Hyon-Xhi Tan, Jennifer Juno

2020-08-29

Characterisation of germinal centre B and T cell responses yields critical insights into vaccine immunogenicity. Non-human primate..

Longitudinal analysis of subtype C envelope tropism for memory CD4( )T cell subsets over the first 3 years of untreated HIV-1 infection

Matthew J Gartner, Paul R Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J Judy Chang, Thomas A Angelovich, Paula Ellenberg, Annemarie E Laumaea, Molati Nonyane, Penny L Moore, Sharon R Lewin, Melissa J Churchill, Jacqueline K Flynn, Michael Roche

2020-08-06

BACKGROUND: HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of ent..

Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation

Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso

2020-08-06

There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

2020-07-13

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

Sequencing B cell receptors from ferrets (Mustela putorius furo)

Julius Wong, Celeste M Tai, Aeron C Hurt, Hyon-Xhi Tan, Stephen J Kent, Adam K Wheatley

2020-05-29

The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunolo..

Immunogenic profile of SARS-CoV-2 spike in individuals recovered from COVID-19

Jennifer Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah Kelly, Kathleen Wragg, Robyn Esterbauer, Helen Kent, Jane Batten, Francesca Mordant, Nicholas Gherardin, Phillip Pymm, Melanie Dietrich, Nichollas Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles Davenport, Stephen Kent, Adam Wheatley

2020-05-21

The rapid global spread of SARS-CoV-2 and resultant mortality and social disruption have highlighted the need to better understand..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

Distinct systems serology features in children, elderly and COVID patients

Kevin Selva, Carolien van de Sandt, Melissa Lemke, Christina Lee, Suzanne Shoffner, Brendon Chua, Thi HO Nguyen, Louise Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, David Jackson, Katie Flanagan, Jane Crowe, Allen Cheng, Denise Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran

2020-05-18

SARS-CoV-2, the pandemic coronavirus that causes COVID-19, has infected millions worldwide, causing unparalleled social and econom..