PATHWAYS TO PRECISION MEDICINE IN EYE DISEASE
Grant number: 1138585 | Funding period: 2019 - 2022
Professor Paul Baird specialises in identifying and understanding how genetic changes associated with common eye diseases including age-related macular degeneration and keratoconus lead to vision loss and blindness. This fellowship will allow him to uncover novel genetic contributors in these diseases using next-generation molecular techniques. He will assess functionality of these variants, allowing him to translate these findings back to the clinic allowing personalised treatment options.
Related publications (11)
Model Structure Uncertainty in the Characterization and Growth of Geographic Atrophy
Janan Arslan, Kurt K Benke, Gihan Samarasinghe, Arcot Sowmya, Robyn H Guymer, Paul N Baird
Purpose: To identify the most suitable model for assessing the rate of growth of total geographic atrophy (GA) by analysis of mode..
Determining the willingness of Australians to export their corneas on death
Heather M Machin, Lisa Buckland, Christine Critchley, Steven Wiffen, Gerard Sutton, Paul N Baird
BACKGROUND: 12.7 million people await a corneal transplant, but 53% are without access to corneal tissue. Sharing corneal tissue a..
Paul N Baird, Seang-Mei Saw, Carla Lanca, Jeremy A Guggenheim, Earl L Smith III, Xiangtian Zhou, Kyoko-Ohno Matsui, Pei-Chang Wu, Padmaja Sankaridurg, Audrey Chia, Mohamad Rosman, Ecosse L Lamoureux, Ryan Man, Mingguang He
Myopia, also known as short-sightedness or near-sightedness, is a very common condition that typically starts in childhood. Severe..
Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations
Heather Machin, Karl Brown, Gerard Sutton, Paul Baird
A 2016 Price Waterhouse Cooper Report, commissioned by the Australian Commonwealth Government's Organ and Tissue Authority, indica..
Economic impact of keratoconus using a health expenditure questionnaire: A patient perspective
Elsie Chan, Paul N Baird, Sara Vogrin, Vijaya Sundararajan, Mark D Daniell, Srujana Sahebjada
IMPORTANCE: This is the first study to estimate the lifetime costs associated with keratoconus based on a questionnaire completed ..
Artificial Intelligence Algorithms for Analysis of Geographic Atrophy: A Review and Evaluation
Janan Arslan, Gihan Samarasinghe, Kurt K Benke, Arcot Sowmya, Zhichao Wu, Robyn H Guymer, Paul N Baird
Purpose: The purpose of this study was to summarize and evaluate artificial intelligence (AI) algorithms used in geographic atroph..
Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration
Laura Lores-Motta, Moeen Riaz, Michelle Grunin, Jordi Corominas, Freekje van Asten, Marc Pauper, Mathieu Leenders, Andrea J Richardson, Philipp Muether, Angela J Cree, Helen L Griffiths, Connie Pham, Marie-Claude Belanger, Magda A Meester-Smoor, Manir Ali, Iris M Heid, Lars G Fritsche, Usha Chakravarthy, Richard Gale, Martin McKibbin
Importance: Visual acuity (VA) outcomes differ considerably among patients with neovascular age-related macular degeneration (nAMD..
Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (CFH) gene family
Stuart Cantsilieris, Bradley J Nelson, John Huddleston, Carl Baker, Lana Harshman, Kelsi Penewit, Katherine M Munson, Melanie Sorensen, AnneMarie E Welch, Vy Dang, Felix Grassmann, Andrea J Richardson, Robyn H Guymer, Tina A Graves-Lindsay, Richard K Wilson, Bernhard HF Weber, Paul N Baird, Rando Allikmets, Evan E Eichler
Structural variation and single-nucleotide variation of the complement factor H (CFH) gene family underlie several complex genetic..