PATHWAYS TO PRECISION MEDICINE IN EYE DISEASE

Grant number: 1138585 | Funding period: 2019 - 2022

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Abstract

Professor Paul Baird specialises in identifying and understanding how genetic changes associated with common eye diseases including age-related macular degeneration and keratoconus lead to vision loss and blindness. This fellowship will allow him to uncover novel genetic contributors in these diseases using next-generation molecular techniques. He will assess functionality of these variants, allowing him to translate these findings back to the clinic allowing personalised treatment options.

Related publications (11)

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Model Structure Uncertainty in the Characterization and Growth of Geographic Atrophy

Janan Arslan, Kurt K Benke, Gihan Samarasinghe, Arcot Sowmya, Robyn H Guymer, Paul N Baird

2021-05-01

Purpose: To identify the most suitable model for assessing the rate of growth of total geographic atrophy (GA) by analysis of mode..

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Determining the willingness of Australians to export their corneas on death

Heather M Machin, Lisa Buckland, Christine Critchley, Steven Wiffen, Gerard Sutton, Paul N Baird

2021-02-19

BACKGROUND: 12.7 million people await a corneal transplant, but 53% are without access to corneal tissue. Sharing corneal tissue a..

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Myopia

Paul N Baird, Seang-Mei Saw, Carla Lanca, Jeremy A Guggenheim, Earl L Smith III, Xiangtian Zhou, Kyoko-Ohno Matsui, Pei-Chang Wu, Padmaja Sankaridurg, Audrey Chia, Mohamad Rosman, Ecosse L Lamoureux, Ryan Man, Mingguang He

2020-12-17

Myopia, also known as short-sightedness or near-sightedness, is a very common condition that typically starts in childhood. Severe..

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Evaluating the Performance of Various Machine Learning Algorithms to Detect Subclinical Keratoconus

Ke Cao, Karin Verspoor, Srujana Sahebjada, Paul N Baird

2020-04-24

Purpose: Keratoconus (KC) represents one of the leading causes of corneal transplantation worldwide. Detecting subclinical KC woul..

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Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations

Heather Machin, Karl Brown, Gerard Sutton, Paul Baird

2020-04-01

A 2016 Price Waterhouse Cooper Report, commissioned by the Australian Commonwealth Government's Organ and Tissue Authority, indica..

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Economic impact of keratoconus using a health expenditure questionnaire: A patient perspective

Elsie Chan, Paul N Baird, Sara Vogrin, Vijaya Sundararajan, Mark D Daniell, Srujana Sahebjada

2020-01-09

IMPORTANCE: This is the first study to estimate the lifetime costs associated with keratoconus based on a questionnaire completed ..

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Artificial Intelligence Algorithms for Analysis of Geographic Atrophy: A Review and Evaluation

Janan Arslan, Gihan Samarasinghe, Kurt K Benke, Arcot Sowmya, Zhichao Wu, Robyn H Guymer, Paul N Baird

2020-01-01

Purpose: The purpose of this study was to summarize and evaluate artificial intelligence (AI) algorithms used in geographic atroph..

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Twin Registries Moving Forward and Meeting the Future: A Review

Paul N Baird, Pirro Hysi

2019-08-01

Twin registries have developed as a valuable resource for the study of many aspects of disease and society over the years in many ..

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Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration

Laura Lores-Motta, Moeen Riaz, Michelle Grunin, Jordi Corominas, Freekje van Asten, Marc Pauper, Mathieu Leenders, Andrea J Richardson, Philipp Muether, Angela J Cree, Helen L Griffiths, Connie Pham, Marie-Claude Belanger, Magda A Meester-Smoor, Manir Ali, Iris M Heid, Lars G Fritsche, Usha Chakravarthy, Richard Gale, Martin McKibbin

2018-08-01

Importance: Visual acuity (VA) outcomes differ considerably among patients with neovascular age-related macular degeneration (nAMD..

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Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (CFH) gene family

Stuart Cantsilieris, Bradley J Nelson, John Huddleston, Carl Baker, Lana Harshman, Kelsi Penewit, Katherine M Munson, Melanie Sorensen, AnneMarie E Welch, Vy Dang, Felix Grassmann, Andrea J Richardson, Robyn H Guymer, Tina A Graves-Lindsay, Richard K Wilson, Bernhard HF Weber, Paul N Baird, Rando Allikmets, Evan E Eichler

2018-05-08

Structural variation and single-nucleotide variation of the complement factor H (CFH) gene family underlie several complex genetic..

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Changing vision: a review of pharmacogenetic studies for treatment response in age-related macular degeneration patients

Janan Arslan, Paul N Baird

2018-04-01

Nonresponsiveness to age-related macular degeneration (AMD) treatments has become a growing concern in ophthalmology. Disparity am..

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