SKELETAL MUSCLE SIGNAL TRANSDUCTION RELATED TO EXERCISE, METABOLIC DISEASE AND HUMAN HEALTH

Grant number: 1122376 | Funding period: 2019 - 2020

Completed

Abstract

Exercise is one of the best prevention and treatment strategies for all major human diseases. Despite these well documented advantages, we still do not know exactly how exercise produces these benefits at the molecular level. A comprehensive understanding of this will lead to new avenues to treat many diseases. This project will monitor thousands of molecular changes that occur in human muscle biopsies following exercise and create the world’s first molecular blueprint of exercise.

Related publications (7)

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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch

2022-10-04

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

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Personalized phosphoproteomics identifies functional signaling

Elise J Needham, Janne R Hingst, Benjamin L Parker, Kaitlin R Morrison, Guang Yang, Johan Onslev, Jonas M Kristensen, Kurt Hojlund, Naomi XY Ling, Jonathan S Oakhill, Erik A Richter, Bente Kiens, Janni Petersen, Christian Pehmoller, David E James, Jorgen FP Wojtaszewski, Sean J Humphrey

2021-12-02

Protein phosphorylation dynamically integrates environmental and cellular information to control biological processes. Identifying..

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Quantification of exercise-regulated ubiquitin signaling in human skeletal muscle identifies protein modification cross talk via NEDDylation

Benjamin L Parker, Bente Kiens, Jorgen FP Wojtaszewski, Erik A Richter, David E James

2020-04-01

The maintenance of muscle function is extremely important for whole body health and exercise is essential to this process. The ubi..

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Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion

Elise J Needham, Sean J Humphrey, Kristen C Cooke, Daniel J Fazakerley, Xiaowen Duan, Benjamin L Parker, David E James

2019-11-05

Exercise engages signaling networks to control the release of circulating factors beneficial to health. However, the nature of the..

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Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.

Janne R Hingst, Lea Bruhn, Mads B Hansen, Marie F Rosschou, Jesper B Birk, Joachim Fentz, Marc Foretz, Benoit Viollet, Kei Sakamoto, Nils J Færgeman, Jesper F Havelund, Benjamin L Parker, David E James, Bente Kiens, Erik A Richter, Jørgen Jensen, Jørgen FP Wojtaszewski

2018-10-01

OBJECTIVE: A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised mu..

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Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training.

Maximilian Kleinert, Benjamin L Parker, Thomas E Jensen, Steffen H Raun, Phung Pham, Xiuqing Han, David E James, Erik A Richter, Lykke Sylow

2018-07-16

Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the..

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Multiplexed Temporal Quantification of the Exercise-regulated Plasma Peptidome.

Benjamin L Parker, James G Burchfield, Daniel Clayton, Thomas A Geddes, Richard J Payne, Bente Kiens, Jørgen FP Wojtaszewski, Erik A Richter, David E James

2017-12-01

Exercise is extremely beneficial to whole body health reducing the risk of a number of chronic human diseases. Some of these physi..

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