A cellular hub for the organisation of T cell priming

Abstract

This project aims to delineate the cellular interactions involved in the initiation of immune responses by utilising advanced in vivo imaging. Adaptive immunity in vertebrates functions via the acquisition of signals by immune cells via complex interactions with other immune cells, yet these exchanges are difficult to observe and define. This project expects to provide insights into the mechanisms that underpin effective cell-mediated immune responses. The expected outcomes are to generate fundamental new knowledge about immune responses and enhance capacity to study the immune system. This could benefit future development of new vaccines and therapies to improve health.

Related publications (1)

Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior

Dominik Schienstock, Scott N Mueller

2021-11-16

The analysis of cellular behavior using intravital multi-photon microscopy has contributed substantially to our understanding of t..