Integrating quantum hyperpolarisation in nuclear magnetic resonance systems
Grant number: DP190101506 | Funding period: 2019 - 2022
This project aims to integrate quantum hyperpolarisation technology into state-of-the-art nuclear magnetic resonance (NMR) systems, potentially boosting the signal by several orders of magnitude. Understanding the structure and function of membrane bound peptides and proteins in cells in their native environments is critical in drug development. However, studying these biomolecules by conventional NMR under ambient conditions is challenging due to sensitivity limitations. The technology developed by this project will be a significant step forward in NMR and the new science enabled may have far reaching consequences for the study of peptides and proteins of live cells for the development of n..View full description
Related publications (17)
The membrane activity of the antimicrobial peptide caerin 1.1 is pH dependent.
Marc-Antoine Sani, Anton P Le Brun, Sunnia Rajput, Troy Attard, Frances Separovic
Antimicrobial peptides are an important class of membrane-active peptides that can provide alternatives or complements to classic ..
Quantum microscopy with van der Waals heterostructures
AJ Healey, SC Scholten, T Yang, JA Scott, GJ Abrahams, IO Robertson, XF Hou, YF Guo, S Rahman, Y Lu, M Kianinia, I Aharonovich, J-P Tetienne
Solid-state spin sensors have the capacity to act as quantum microscopes for probing material properties and physical processes. H..
Varied Magnetic Phases in a van der Waals Easy-Plane Antiferromagnet Revealed by Nitrogen-Vacancy Center Microscopy
Alexander J Healey, Sharidya Rahman, Sam C Scholten, Islay O Robertson, Gabriel J Abrahams, Nikolai Dontschuk, Boqing Liu, Lloyd CL Hollenberg, Yuerui Lu, Jean-Philippe Tetienne
Interest in van der Waals materials often stems from a desire to miniaturize existing technologies by exploiting their intrinsic l..
Imaging Current Paths in Silicon Photovoltaic Devices with a Quantum Diamond Microscope
SC Scholten, GJ Abrahams, BC Johnson, AJ Healey, IO Robertson, DA Simpson, A Stacey, S Onoda, T Ohshima, TC Kho, J Ibarra Michel, J Bullock, LCL Hollenberg, J-P Tetienne
Magnetic imaging with nitrogen-vacancy centers in diamond, also known as quantum diamond microscopy, has emerged as a useful techn..
In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide.
Frances Separovic, Vinzenz Hofferek, Anthony P Duff, Malcom J McConville, Marc-Antoine Sani
Dynamic nuclear polarization NMR spectroscopy was used to investigate the effect of the antimicrobial peptide (AMP) maculatin 1.1 ..
An integrated widefield probe for practical diamond nitrogen-vacancy microscopy
GJ Abrahams, SC Scholten, AJ Healey, IO Robertson, N Dontschuk, SQ Lim, BC Johnson, DA Simpson, LCL Hollenberg, J-P Tetienne
The widefield diamond nitrogen-vacancy (NV) microscope is a powerful instrument for imaging magnetic fields. However, a key limita..
TOAC spin-labeled peptides tailored for DNP-NMR studies in lipid membrane environments
Shiying Zhu, Ehsan Kachooei, Jeffrey R Harmer, Louise J Brown, Frances Separovic, Marc-Antoine Sani
The benefit of combining in-cell solid-state dynamic nuclear polarization (DNP) NMR and cryogenic temperatures is providing suffic..
Advances in the Surface Functionalization of Nanodiamonds for Biological Applications: A Review
Mina Barzegar Amiri Olia, Paul S Donnelly, Lloyd CL Hollenberg, Paul Mulvaney, David A Simpson
Nanodiamonds (NDs) represent an emerging class of nanomaterials that have been used for a variety of applications including biosen..
Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides
Sunnia Rajput, Marc-Antoine Sani, David W Keizer, Frances Separovic
Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques p..
Polarization Transfer to External Nuclear Spins Using Ensembles of Nitrogen-Vacancy Centers
AJ Healey, LT Hall, GAL White, T Teraji, M-A Sani, F Separovic, J-P Tetienne, LCL Hollenberg
The nitrogen-vacancy (N-V) center in diamond has emerged as a candidate to noninvasively hyperpolarize nuclear spins in molecular ..
C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1
Shiying Zhu, Wenyi Li, Neil O'Brien-Simpson, Frances Separovic, Marc-Antoine Sani
Cationic antimicrobial peptides have been investigated for their potential use in combating infections by targeting the cell membr..
Prospects for nuclear spin hyperpolarization of molecular samples using nitrogen-vacancy centers in diamond
J-P Tetienne, LT Hall, AJ Healey, GAL White, M-A Sani, F Separovic, LCL Hollenberg
After initial proof-of-principle demonstrations, optically pumped nitrogen-vacancy (NV) centers in diamond have been proposed as a..
Comparison of different methods of nitrogen-vacancy layer formation in diamond for wide-field quantum microscopy
AJ Healey, A Stacey, BC Johnson, DA Broadway, T Teraji, DA Simpson, J-P Tetienne, LCL Hollenberg
Thin layers of near-surface nitrogen-vacancy (NV) defects in diamond substrates are the workhorse of NV-based wide-field magnetic ..
Imaging Domain Reversal in an Ultrathin Van der Waals Ferromagnet
David A Broadway, Sam C Scholten, Cheng Tan, Nikolai Dontschuk, Scott E Lillie, Brett C Johnson, Guolin Zheng, Zhenhai Wang, Artem R Oganov, Shangjie Tian, Chenghe Li, Hechang Lei, Lan Wang, Lloyd CL Hollenberg, Jean-Philippe Tetienne
The recent isolation of 2D van der Waals magnetic materials has uncovered rich physics that often differs from the magnetic behavi..
Improved Current Density and Magnetization Reconstruction Through Vector Magnetic Field Measurements
DA Broadway, SE Lillie, SC Scholten, D Rohner, N Dontschuk, P Maletinsky, J-P Tetienne, LCL Hollenberg
Stray magnetic fields contain significant information about the electronic and magnetic properties of condensed matter systems. Fo..
Laser Modulation of Superconductivity in a Cryogenic Wide-field Nitrogen-Vacancy Microscope.
Scott E Lillie, David A Broadway, Nikolai Dontschuk, Sam C Scholten, Brett C Johnson, Sebastian Wolf, Stephan Rachel, Lloyd CL Hollenberg, Jean-Philippe Tetienne
We realize a cryogenic wide-field nitrogen-vacancy microscope and use it to image Abrikosov vortices and transport currents in a s..