Studying early human kidney development using stem cells
Grant number: DP190101705 | Funding period: 2019 - 2022
This project aims to improve our understanding of cell types, lineage relationships, cell-cell interactions and morphogenetic processes in human kidney development. Investigators have developed a method to produce multicellular kidney organoids from human pluripotent stem cells (hPSC). This project will use gene-edited reporter hPSC lines and high-res imaging to study the lineage relationships and morphogenetic mechanisms of these human kidney organoids. This project aims to validate the origin of nephrons in kidney organoids, study the origin of the renal stroma versus the nephron progenitor, and monitor nephron patterning and segmentation at a clonal level. This will improve our knowledge ..View full description
Related publications (5)
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk
Sara E Howden, Sean B Wilson, Ella Groenewegen, Lakshi Starks, Thomas A Forbes, Ker Sin Tan, Jessica M Vanslambrouck, Emily M Holloway, Yi-Hsien Chen, Sanjay Jain, Jason R Spence, Melissa H Little
During development, distinct progenitors contribute to the nephrons versus the ureteric epithelium of the kidney. Indeed, previous..