Molecular study of copper-promoted ubiquitination
Grant number: DP190102573 | Funding period: 2019 - 2021
This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2D2 promotes ubiquitination of a range of proteins including tumor suppressor p53. It predicts a correlation between copper homeostasis and cellular proteostasis and may rationalise an inverse relationship between Alzheimer's disease and cancer. This project will employ a range of integrated approaches to illuminate the molecular nature of this copper action. Expected outcomes include an understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration. Potential benefits include new strategies to intervene in copper-..View full description
Related publications (1)
The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistance
Pramod Subedi, Jason J Paxman, Geqing Wang, Ashwinie A Ukuwela, Zhiguang Xiao, Begona Heras
The human pathogen Salmonella enterica serovar Typhimurium (S Typhimurium) contains a complex disulfide bond (Dsb) catalytic machi..