DNA printing on a synthetic polymer template
Grant number: DP190100055 | Funding period: 2019 - 2023
This project aims to design and study DNA printing to manufacture long strands of DNA using simple but elegant fundamental non-enzymatic chemical reactions. Gene therapy is one of the most rapidly growing therapies in modern medicine but it is prohibitively expensive for the average person. Current methods of artificial gene synthesis are complicated with commercial DNA synthesis only supplying short DNA strands. The project outcomes will lead to a stable template directing the chemical reactions for DNA printing. This new approach will make life-saving gene therapy cheaper and more widely available for future generations and provide economic, and social benefits to all Australians.
Related publications (3)
Enhancement of DNAzymatic activity using iterative in silico maturation
Renzo A Fenati, Zifei Chen, Yasuko Yamagishi, Kaori Tsukakoshi, Kazunori Ikebukuor, Anjay Manian, Salvy P Russo, Tomohiko Yamazaki, Amanda Ellis
DNAzyme-based (catalytic nucleic acid) biosensing technology is recognised as a valuable biosensing tool in diagnostic medicine an..
Biofunctionality with a twist: the importance of molecular organisation, handedness and configuration in synthetic biomaterial design
Simone IS Hendrikse, Rafael Contreras-Montoya, Amanda Ellis, Pall Thordarson, Jonathan W Steed
The building blocks of life - nucleotides, amino acids and saccharides - give rise to a large variety of components and make up th..