THE METASTABILITY OF PROTEOME FOLDEDNESS IN NEURODEGENERATIVE DISEASE

Grant number: 1161803 | Funding period: 2019 - 2023

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Abstract

Proteins are used by cells to control almost all their functions. A key feature of neurodegenerative diseases, like Alzheimer’s and Huntington’s is that certain proteins abnormally aggregate together which interferes with biological function. This grant seeks to understand why this happens and what the implications are for cellular survival. Gaining this knowledge will aid in the design of therapies combat this abnormality or prevent the damage that is caused by it.

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