THE METASTABILITY OF PROTEOME FOLDEDNESS IN NEURODEGENERATIVE DISEASE
Grant number: 1161803 | Funding period: 2019 - 2022
The research objective of this award is to develop a quantitative and mechanistic understanding of how the genomic material of viruses enters the cells they are infecting. Cells across all domains of life are subjected to infection by viruses. These viruses have a multitude of different lifestyles which often involve different ways of introducing their genes into the infected host. For some of these viruses, it has been hypothesized that mechanical forces resulting from the tightly-packaged DNA within the virus creates a pressure which injects the DNA into the host?s interior. Studies conducted under this award will test this hypothesis by using fluorescence microscopy to watch individual vi..View full description
Related publications (8)
Immiscible inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation
Mona Radwan, Jordan D Lilley, Ching-Seng Ang, Gavin E Reid, Danny M Hatters
Poly(glycine-alanine) (polyGA) is one of the polydipeptides expressed in Frontotemporal Dementia and/or Amyotrophic Lateral Sclero..
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA
Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters
Mutations that cause Huntington's Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..
A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment
Tze Cin Owyong, Pramod Subedi, Jieru Deng, Elizabeth Hinde, Jason J Paxman, Jonathan M White, Weisan Chen, Begona Heras, Wallace WH Wong, Yuning Hong
Environmental polarity is an important factor that drives biomolecular interactions to regulate cell function. Herein, a general m..
Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation
Mona Radwan, Jordan Lilley, Ching-Seng Ang, Gavin Reid, Danny Hatters
<h4>ABSTRACT</h4> Poly(glycine-alanine) (polyGA) is one of the dipolypeptides expressed in Motor Neuron Disease caused by C9ORF72 ..
Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity
Mona Radwan, Ching-Seng Ang, Angelique R Ormsby, Dezerae Cox, James C Daly, Gavin E Reid, Danny M Hatters
C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used qu..
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses
Xiaojing Sui, Douglas EV Pires, Angelique R Ormsby, Dezerae Cox, Shuai Nie, Giulia Vecchi, Michele Vendruscolo, David B Ascher, Gavin E Reid, Danny M Hatters
The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vul..
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal
Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H Dillingham, Bernadette A Chua, Miriama Kruta, Yuning Hong, Danny M Hatters, Robert AJ Signer
Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in prote..