Statistical methods for modelling the pathways between cause and effect
Grant number: DE190101326 | Funding period: 2019 - 2022
This project aims to develop new biostatistical methods for addressing complex analytic questions that arise in studies of the causes of health, social, educational and other outcomes in the course of human life. These questions concern the pathways that explain how intermediate factors contribute to a statistical relationship between a probable cause of a later outcome. Mathematical and statistical innovation is needed to address them. The expected outcomes include a suite of novel methods designed to evaluate the impact of intervening to modify causal pathways, while also accommodating common complexities of data such as incompleteness. This project should provide major benefits to studies..View full description
Related publications (4)
Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis.
S Ghazaleh Dashti, Dallas R English, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Anne Tjønneland, Jytte Halkjær, Christina C Dahm, Helene Tilma Vistisen, Florence Menegaux, Vittorio Perduca, Gianluca Severi, Krasimira Aleksandrova, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Rosario Tumino
BACKGROUND: Adiposity increases endometrial cancer risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens..
Parental mental health before and during pregnancy and offspring birth outcomes: A 20-year preconception cohort of maternal and paternal exposure.
Elizabeth A Spry, Claire A Wilson, Melissa Middleton, Margarita Moreno-Betancur, Lex W Doyle, Louise M Howard, Anthony J Hannan, Mary E Wlodek, Jeanie Ly Cheong, Lindsey A Hines, Carolyn Coffey, Stephanie Brown, Craig A Olsson, George C Patton
Background: Preterm birth (PTB) and small for gestational age (SGA) are increasingly prevalent, with major consequences for health..
Explaining the link between adiposity and colorectal cancer risk in men and postmenopausal women in the UK Biobank: A sequential causal mediation analysis
S Ghazaleh Dashti, Vivian Viallon, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Dallas R English, Marc J Gunter, Neil Murphy
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Using UK Biobank data, we investi..
Inflammation mediates the relationship between obesity and retinal vascular calibre in 11-12 year-olds children and mid-life adults
Mengjiao Liu, Kate Lycett, Margarita Moreno-Betancur, Tien Yin Wong, Mingguang He, Richard Saffery, Markus Juonala, Jessica A Kerr, Melissa Wake, David P Burgner
Obesity predicts adverse microvasculature from childhood, potentially via inflammatory pathways. We investigated whether inflammat..