UNDERSTANDING THE ASSEMBLY OF THE COMMANDER COMPLEX
Grant number: 1156732 | Funding period: 2019 - 2022
Controlling the synthesis, recycling and degradation of receptors in the cell is absolutely essential for normal cellular function, regulating processes as diverse as the metabolism and synaptic communication. This project we will determine how Commander, a protein machine that controls retrieval, export and recycling of receptors is assembled as a large multi subunit assembly. This will provide insights into how Commander regulates complex pathways of cellular homeostasis in health and disease.
Related publications (2)
Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins
Michael D Healy, Joanna Sacharz, Kerrie E McNally, Calum McConville, Vikas A Tillu, Ryan J Hall, Molly Chilton, Peter J Cullen, Mehdi Mobli, Rajesh Ghai, David A Stroud, Brett M Collins
The sorting nexin SNX17 controls endosomal recycling of transmembrane cargo proteins including integrins, the amyloid precursor pr..
De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
Kai-En Chen, Qian Guo, Timothy A Hill, Yi Cui, Amy K Kendall, Zhe Yang, Ryan J Hall, Michael D Healy, Joanna Sacharz, Suzanne J Norwood, Sachini Fonseka, Boyang Xie, Robert C Reid, Natalya Leneva, Robert G Parton, Rajesh Ghai, David A Stroud, David P Fairlie, Hiroaki Suga, Lauren P Jackson
The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane trafficking and signaling. Mutation of the retromer s..