Targeting the Epigenome for Therapeutic Gain in Cancer

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

O Gilan, I Rioja, K Knezevic, MJ Bell, MM Yeung, NR Harker, EYN Lam, C Chung, P Bamborough, M Petretich, M Urh, SJ Atkinson, AK Bassil, EJ Roberts, D Vassiliadis, ML Burr, AGS Preston, C Wellaway, T Werner, JR Gray

2020-04-24

The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins enable chromatin binding to facilitate tran..