New Aminobenzimidazole Antimalarial Agents With a Novel Mechanism of Action

Discovery and development of 2-aminobenzimidazoles as potent antimalarials

SM Devine, MP Challis, JK Kigotho, G Siddiqui, A De Paoli, CA MacRaild, VM Avery, DJ Creek, RS Norton, PJ Scammells

2021-10-05

The emergence of Plasmodium falciparum resistance to frontline antimalarials, including artemisinin combination therapies, highlig..

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

TD Ashton, SM Devine, JJ Möhrle, B Laleu, JN Burrows, SA Charman, DJ Creek, BE Sleebs

2019-12-12

Malaria is a devastating disease caused by Plasmodium parasites, resulting in approximately 435000 deaths in 2018. The impact of m..