THE UNIQUE NATURE OF GAMMA DELTA T CELL RECOGNITION RESOLVED THROUGH INTERACTION WITH H2-Q10
Grant number: 1141950 | Funding period: 2019 - 2020
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Related publications (3)
Ribosylation of the CD8αβ heterodimer permits binding of the non-classical major histocompatibility molecule, H2-Q10.
Katharine Jennifer Goodall, Angela Nguyen, Daniel Mark Andrews, Lucy Catherine Sullivan
The CD8αβ heterodimer plays a crucial role in the stabilisation between major histocompatibility complex class I molecules (MHC-I)..
The murine CD94/NKG2 ligand, Qa-1(b), is a high-affinity, functional ligand for the CD8?? homodimer
Katharine Jennifer Goodall, Angela Nguyen, Craig McKenzie, Sidonia Barbara Guiomar Eckle, Lucy Catherine Sullivan, Daniel Mark Andrews
The immune co-receptor CD8 molecule (CD8) has two subunits, CD8α and CD8β, which can assemble into homo or heterodimers. Nonclassi..
Multiple receptors converge on H2-Q10 to regulate NK and gamma delta T-cell development
Katharine J Goodall, Angela Nguyen, Aya Matsumoto, Julie R McMullen, Sidonia B Eckle, Patrick Bertolino, Lucy C Sullivan, Daniel M Andrews
Class Ib major histocompatibility complex (MHC) is an extended family of molecules, which demonstrate tissue-specific expression a..