NOVEL EARLY DETECTION STRATEGY FOR LIVER CANCER USING HEPATITIS B SPLICE VARIANTS TO EXPEDIATE DIAGNOSIS AND IMPROVE TREATMENT OUTCOME
Grant number: 1145977 | Funding period: 2018 - 2021
Hepatitis B virus (HBV) causes liver cancer, which is one of the only cancers that is increasing in prevalence. We have shown that smaller versions of HBV, termed splice variants, are even more strongly associated with liver cancer- people with higher levels of the splice variants were over 3 times more likely to have liver cancer. We will find out why, by thoroughly studying how the splice variants alter the virus and the host cell to promote liver cancer.
Related publications (4)
Secreted hepatitis B virus splice variants differ by HBV genotype and across phases of chronic hepatitis B infection
Olivia Maslac, Josef Wagner, Vitina Sozzi, Hugh Mason, Jenny Svarovskaia, Susanna Tan, Anuj Gaggar, Stephen Locarnini, Lilly Yuen, Margaret Littlejohn, Peter A Revill
Chronic hepatitis B (CHB) is characterized by progression through different phases of hepatitis B virus (HBV) infection and diseas..
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models
Michelle P Clark, Thao Huynh, Shringar Rao, Liana Mackiewicz, Hugh Mason, Shahla Romal, Michael D Stutz, Sang H Ahn, Linda Earnest, Vitina Sozzi, Margaret Littlejohn, Bang M Tran, Norbert Wiedemann, Elizabeth Vincan, Joseph Torresi, Hans J Netter, Tokameh Mahmoudi, Peter Revill, Marc Pellegrini, Gregor Ebert
A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individ..
Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes
Chun Shen Lim, Vitina Sozzi, Margaret Littlejohn, Lilly KW Yuen, Nadia Warner, Brigid Betz-Stablein, Fabio Luciani, Peter A Revill, Chris M Brown
Hepatitis B virus (HBV) is a major human pathogen that causes liver diseases. The main HBV RNAs are unspliced transcripts that enc..