ADENOSINE RECEPTOR CONTEXT-SPECIFIC BIASED AGONISM TO TREAT ISCHAEMIC HEART DISEASE
Grant number: 1147291 | Funding period: 2018 - 2020
Heart attacks and secondary heart failure remain significant health burdens. Stimulation of adenosine receptors located on heart cells confers powerful cardiac protection, improving acute and longer-term heart function subsequent to a heart attack but avoiding the usual unwanted effects from this approach. We aim to better understand the mechanism of action of potential adenosine receptor therapeutics and establish the clinical potential of these compounds using animal models of heart failure.
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Positive allosteric mechanisms of adenosine A(1) receptor-mediated analgesia
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The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain1,2. Ho..