DO BREAST CANCER RISK FACTORS DIFFER ACCORDING TO UNDERLYING GENETIC SUSCEPTIBILITY? A POOLED ANALYSIS OF PROSPECTIVE STUDIES FROM THE NCI CANCER COHORT CONSORTIUM

Abstract

We propose to use data from 23 international prospective cohort studies in the Cancer Cohort Consortium organised by the US National Cancer Institute to evaluate gene environment interactions for women who are at increased genetic risk of breast cancer. Our ultimate goal is to enhance the performance of clinical prediction tools and to develop targeted evidence-based strategies to mitigate the high absolute risk of breast cancer for women at increased genetic risk of the disease.