CENTRE FOR TRANSLATIONAL BREAST CANCER RESEARCH (TRANSBCR): DELIVERING LABORATORY DISCOVERIES TO THE CLINIC

R code and downstream analysis objects for the scRNA-seq atlas of normal and tumorigenic human breast tissue

Yunshun Chen, Bhupinder Pal, Geoffrey J Lindeman, Jane E Visvader, Gordon K Smyth

2022-03-23

Breast cancer is a common and highly heterogeneous disease. Understanding cellular diversity in the mammary gland and its surround..

A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

Bhupinder Pal, Yunshun Chen, Francois Vaillant, Bianca D Capaldo, Rachel Joyce, Xiaoyu Song, Vanessa L Bryant, Jocelyn S Penington, Leon Di Stefano, Nina Tubau Ribera, Stephen Wilcox, Gregory B Mann, Anthony T Papenfuss, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

2021-05-05

To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,0..

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer

James R Whittle, Francois Vaillant, Elliot Surgenor, Antonia N Policheni, Goknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman

2020-08-01

PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Johanna F Dekkers, James R Whittle, Francois Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten H Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader

2020-05-01

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..