Centre for Translational Breast Cancer Research (Transbcr): Delivering Laboratory Discoveries to the Clinic

Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells

MJG Milevskiy, HD Coughlan, SR Kane, TM Johanson, S Kordafshari, WF Chan, M Tsai, E Surgenor, S Wilcox, RS Allan, Y Chen, GJ Lindeman, GK Smyth, JE Visvader

2023-11-08

Although lineage-specific genes have been identified in the mammary gland, little is known about the contribution of the 3D genome..

Universal genetic testing for women with newly diagnosed breast cancer in the context of multidisciplinary team care

DL De Silva, L Stafford, AR Skandarajah, M Sinclair, L Devereux, K Hogg, M Kentwell, A Park, L Lal, M Zethoven, MW Jayawardana, F Chan, PN Butow, PA James, GB Mann, IG Campbell, GJ Lindeman

2023-05-01

Objective: To determine the feasibility of universal genetic testing of women with newly diagnosed breast cancer, to estimate the ..

R code and downstream analysis objects for the scRNA-seq atlas of normal and tumorigenic human breast tissue

Y Chen, B Pal, GJ Lindeman, JE Visvader, GK Smyth

2022-12-01

Breast cancer is a common and highly heterogeneous disease. Understanding cellular diversity in the mammary gland and its surround..

A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

B Pal, Y Chen, F Vaillant, BD Capaldo, R Joyce, X Song, VL Bryant, JS Penington, L Di Stefano, N Tubau Ribera, S Wilcox, GB Mann, AT Papenfuss, GJ Lindeman, GK Smyth, JE Visvader

2021-06-01

To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,0..

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor–Positive Breast Cancer

JR Whittle, F Vaillant, E Surgenor, AN Policheni, G Giner, BD Capaldo, HR Chen, HK Liu, JF Dekkers, N Sachs, H Clevers, A Fellowes, T Green, H Xu, SB Fox, MJ Herold, GK Smyth, DHD Gray, JE Visvader, GJ Lindeman

2020-08-01

Purpose: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

JF Dekkers, JR Whittle, F Vaillant, HR Chen, C Dawson, K Liu, MH Geurts, MJ Herold, H Clevers, GJ Lindeman, JE Visvader

2020-05-01

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..