Improving the Diagnostic Accuracy and Treatment Options for Equine Ppid

The detection of ACTH and insulin in equine plasma by solid-phase extraction and micro-flow LC/MSMS

R Steel, M Timms, N Bamford, R Spence, M Sillence

2025-05-01

Previous liquid chromatography/mass spectrometry (LC/MS) methods for the detection of insulin and other similar peptide hormones i..

Effect of pergolide treatment on insulin dysregulation in horses and ponies with pituitary pars intermedia dysfunction

NC Galinelli, NJ Bamford, ML Erdody, SA Mackenzie, T Warnken, PA Harris, MN Sillence, SR Bailey

2025-01-01

Background: Due to the high frequency of laminitis reported for both conditions, the relationship between pituitary pars intermedi..

Effect of short-term dopamine reduction on insulin sensitivity and post-prandial insulin and glucose responses in Standardbred horses

NC Galinelli, NJ Bamford, ML Erdody, T Warnken, MA de Laat, MN Sillence, PA Harris, SR Bailey

2025-01-01

The role of dopamine in the regulation of insulin secretion in horses is poorly understood and requires further investigation. Pit..

Physiological and metabolic effects of short-term dopamine reduction in healthy horses using a tyrosine hydroxylase inhibitor (alpha-methyl-para-tyrosine)

Nicolas C Galinelli, Nicholas J Bamford, Madison L Erdody, Tobias Warnken, Melody A de Laat, Martin N Sillence, Patricia A Harris, Simon R Bailey

2024-10-01

Alpha-methyl-para-tyrosine (AMPT) is a reversible inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine syn..

Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas

NC Galinelli, NJ Bamford, MA de Laat, MN Sillence, PA Harris, SR Bailey

2024-02-01

Insulin dysregulation in horses is characterised by hyperinsulinaemia and/or tissue insulin resistance and is associated with incr..

Association between insulin dysregulation and adrenocorticotropic hormone in aged horses and ponies with no clinical signs of pituitary pars intermedia dysfunction

FI Li, RJ Spence, MA de Laat, PA Harris, J Sonntag, NJ Menzies-Gow, AE Durham, SR Bailey, MN Sillence

2023-11-01

Background: High concentrations of adrenocorticotropic hormone (ACTH) are used as an indicator of pituitary pars intermedia dysfun..

Nutritional considerations for the management of equine pituitary pars intermedia dysfunction

NC Galinelli, SR Bailey, NJ Bamford, PA Harris

2023-01-01

Pituitary pars intermedia dysfunction (PPID) is a common endocrine disorder affecting equids. To help achieve and maintain healthy..