The Molecular Control of Lymphatic Vascular Differentiation

Grant number: DP180102846 | Funding period: 2018 - 2020

Completed

Abstract

This project aims to improve our understanding of how a new vascular system forms and the molecules that control this process. Lymphatic vasculature plays roles in fluid drainage, inflammation, obesity, metastasis and tissue repair, yet we cannot readily promote or inhibit lymphatic vessel formation. This project aims to build new knowledge that is expected to improve our ability to generate lymphatic vessels for stem cell applications, tissue engineering, tissue repair and regeneration. This project will use zebrafish embryos, new genomic datasets and novel tools to uncover the genetic control of this process, and should have implications in stem cell biology, tissue engineering, repair and..

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Related publications (2)

Single-cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development

L Grimm, E Mason, H Yu, S Dudczig, V Panara, T Chen, NI Bower, S Paterson, M Rondon Galeano, S Kobayashi, A Senabouth, AK Lagendijk, J Powell, KA Smith, KS Okuda, K Koltowska, BM Hogan

2023-06-01

During development, the lymphatic vasculature forms as a second network derived chiefly from blood vessels. The transdifferentiati..

Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo

Smrita Chaudhury, Kazuhide S Okuda, Katarzyna Koltowska, Anne K Lagendijk, Scott Paterson, Gregory J Baillie, Cas Simons, Kelly A Smith, Benjamin M Hogan, Neil Bower

2020-09-01

The lymphatic vasculature develops primarily from pre-existing veins. A pool of lymphatic endothelial cells (LECs) first sprouts f..

University of Melbourne Researchers

Benjamin Hogan