APPLYING PATHOGEN GENOMICS TO THE PREVENTION AND CONTROL OF ANTIMICROBIAL RESISTANCE
Grant number: 1174555 | Funding period: 2020 - 2024
Related publications (22)
Tuberculosis in Australia's tropical north: a population-based genomic epidemiological study.
Ella M Meumann, Kristy Horan, Anna P Ralph, Belinda Farmer, Maria Globan, Elizabeth Stephenson, Tracy Popple, Rowena Boyd, Mirjam Kaestli, Torsten Seemann, Koen Vandelannoote, Christopher Lowbridge, Robert W Baird, Timothy P Stinear, Deborah A Williamson, Bart J Currie, Vicki L Krause
Background: The Northern Territory (NT) has the highest tuberculosis (TB) rate of all Australian jurisdictions. We combined TB pub..
Treponema pallidum detection in lesion and non-lesion sites in men who have sex with men with early syphilis: a prospective, cross-sectional study
Janet M Towns, David E Leslie, Ian Denham, Rebecca Wigan, Francesca Azzato, Deborah A Williamson, Darren Lee, Eric PF Chow, Christopher K Fairley, Stephen R Graves, Lei Zhang, Marcus Y Chen
BACKGROUND: Syphilis transmission is increasing, and precisely how Treponema pallidum is transmitted sexually from person to perso..
Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,,12:i:- in Australia
Danielle J Ingle, Rebecca L Ambrose, Sarah L Baines, Sebastian Duchene, Anders Goncalves da Silva, Darren YJ Lee, Miriam Jones, Mary Valcanis, George Taiaroa, Susan A Ballard, Martyn D Kirk, Benjamin P Howden, Jaclyn S Pearson, Deborah A Williamson
Salmonella enterica serovar 4,,12:i:- (Salmonella 4,,12:i:-) is a monophasic variant of Salmonella Typhimurium that has emer..
Genomics-informed responses in the elimination of COVID-19 in Victoria, Australia: an observational, genomic epidemiological study
Courtney R Lane, Norelle L Sherry, Ashleigh F Porter, Sebastian Duchene, Kristy Horan, Patiyan Andersson, Mathilda Wilmot, Annabelle Turner, Sally Dougall, Sandra A Johnson, Michelle Sait, Anders Gonsalves da Silva, Susan A Ballard, Tuyet Hoang, Timothy P Stinear, Leon Caly, Vitali Sintchenko, Rikki Graham, Jamie McMahon, David Smith
BACKGROUND: A cornerstone of Australia's ability to control COVID-19 has been effective border control with an extensive supervise..
An implementation science approach to evaluating pathogen whole genome sequencing in public health
Angeline S Ferdinand, Margaret Kelaher, Courtney R Lane, Anders Goncalves da Silva, Norelle L Sherry, Susan A Ballard, Patiyan Andersson, Tuyet Hoang, Justin T Denholm, Marion Easton, Benjamin P Howden, Deborah A Williamson
BACKGROUND: Pathogen whole genome sequencing (WGS) is being incorporated into public health surveillance and disease control syste..
A comparison of cotton-tipped and nylon flocked swabs for culture of Neisseria gonorrhoeae from oropharyngeal samples.
Tiffany R Phillips, Marjan Tabesh, Christopher K Fairley, Kate Maddaford, Shivani Pasricha, Rebecca Wigan, Vesna De Petra, Deborah A Williamson, Eric PF Chow
Our aim was to determine if there was a difference in culture positivity for oropharyngeal gonorrhoea when sampling using a nylon-..
Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei
Jane Hawkey, Kalani Paranagama, Kate S Baker, Rebecca J Bengtsson, Francois-Xavier Weill, Nicholas R Thomson, Stephen Baker, Louise Cerdeira, Zamin Iqbal, Martin Hunt, Danielle J Ingle, Timothy J Dallman, Claire Jenkins, Deborah A Williamson, Kathryn E Holt
Shigella sonnei is the most common agent of shigellosis in high-income countries, and causes a significant disease burden in low- ..
Modelling the contribution that different sexual practices involving the oropharynx and saliva have on Neisseria gonorrhoeae infections at multiple anatomical sites in men who have sex with men
Xianglong Xu, Eric PF Chow, Jason J Ong, Christian JPA Hoebe, Deborah Williamson, Mingwang Shen, Fabian Yuh Shiong Kong, Jane S Hocking, Christopher K Fairley, Lei Zhang
BACKGROUND: The spectrum of sexual practices that transmit Neisseria gonorrhoeae in men who have sex with men (MSM) is controversi..
Reflex Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of the SpeeDx ResistancePlus GC Assay
Darren YJ Lee, Melinda M Ashcroft, Eric PF Chow, Michelle Sait, Vesna De Petra, Marlene Tschaepe, Sigrid Lange, George Taiaroa, Catriona S Bradshaw, David M Whiley, Christopher K Fairley, Benjamin P Howden, Marcus Y Chen, Shivani Pasricha, Deborah A Williamson
Resistance-guided therapy (RGT) for gonorrhea may reduce unnecessary use of broad-spectrum antibiotics. When reflexed from the Apt..
Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study
Stephen Muhi, Nick Tayler, Tuyet Hoang, Susan A Ballard, Maryza Graham, Amanda Rojek, Jason C Kwong, Jason A Trubiano, Olivia Smibert, George Drewett, Fiona James, Emma Gardiner, Socheata Chea, Nicole Isles, Michelle Sait, Shivani Pasricha, George Taiaroa, Julie McAuley, Eloise Williams, Katherine B Gibney
Background: In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, few ..
Timing of primary syphilis treatment and impact on the development of treponemal antibodies: a cross-sectional clinic-based study.
Janet M Towns, David E Leslie, Ian Denham, Francesca Azzato, Theo Karapanagiotidis, Deborah A Williamson, Stephen R Graves, Christopher K Fairley, Melanie Bissessor, Eric PF Chow, Lei Zhang, Marcus Y Chen
BACKGROUND: Serology is negative in a proportion of primary syphilis cases where Treponema pallidum PCR testing is positive. We ai..
Culture obtained from urethral swab of asymptomatic men who screen positive for Neisseria gonorrhoeae by urine nucleic acid amplification testing.
Ayoma Ratnappuli, Melanie Bissessor, Shehara Arumugam, Deborah A Williamson, Eric PF Chow, Christopher K Fairley, Jason J Ong, Vesna De Petra, Marcus Y Chen
BACKGROUND: In a previous study of men attending Melbourne Sexual Health Centre who had Neisseria gonorrhoeae detected by urine Ap..
An open-label, parallel-group, randomised controlled trial of antiseptic mouthwash versus antibiotics for oropharyngeal gonorrhoea treatment (OMEGA2)
Eric PF Chow, Kate Maddaford, Jane S Hocking, Catriona S Bradshaw, Rebecca Wigan, Marcus Y Chen, Benjamin P Howden, Deborah A Williamson, Christopher K Fairley
New treatments for oropharyngeal gonorrhoea are required to address rising antimicrobial resistance. We aimed to examine the effic..
Treatment efficacy for pharyngeal Neisseria gonorrhoeae: a systematic review and meta-analysis of randomized controlled trials
Fabian YS Kong, Christina L Hatzis, Andrew Lau, Deborah A Williamson, Eric PF Chow, Christopher K Fairley, Jane S Hocking
BACKGROUND: Rising gonorrhoea rates require highly effective treatments to reduce transmission and prevent development of antimicr..
Evaluation of Serological Tests for SARS-CoV-2: Implications for Serology Testing in a Low-Prevalence Setting
Katherine Bond, Suellen Nicholson, Seok Ming Lim, Theo Karapanagiotidis, Eloise Williams, Douglas Johnson, Tuyet Hoang, Cheryll Sia, Damian Purcell, Francesca Mordant, Sharon R Lewin, Mike Catton, Kanta Subbarao, Benjamin P Howden, Deborah A Williamson
BACKGROUND: Robust serological assays are essential for long-term control of the COVID-19 pandemic. Many recently released point-o..
Changing from Clinician-Collected to Self-Collected Throat Swabs for Oropharyngeal Gonorrhea and Chlamydia Screening among Men Who Have Sex with Men
Eric PF Chow, Catriona S Bradshaw, Deborah A Williamson, Shauna Hall, Marcus Y Chen, Tiffany R Phillips, Ria Fortune, Kate Maddaford, Christopher K Fairley
The coronavirus disease 2019 (COVID-19) pandemic has led many clinics to move from clinician-collected to self-collected oropharyn..
Pandemic printing: a novel 3D-printed swab for detecting SARS-CoV-2
Eloise Williams, Katherine Bond, Nicole Isles, Brian Chong, Douglas Johnson, Julian Druce, Tuyet Hoang, Susan A Ballard, Victoria Hall, Stephen Muhi, Kirsty L Buising, Seok Lim, Dick Strugnell, Mike Catton, Louis B Irving, Benjamin P Howden, Eric Bert, Deborah A Williamson
OBJECTIVES: To design and evaluate 3D-printed nasal swabs for collection of samples for SARS-CoV-2 testing. DESIGN: An iterative d..
Tracking the COVID-19 pandemic in Australia using genomics
Torsten Seemann, Courtney R Lane, Norelle L Sherry, Sebastian Duchene, Anders Goncalves da Silva, Leon Caly, Michelle Sait, Susan A Ballard, Kristy Horan, Mark B Schultz, Tuyet Hoang, Marion Easton, Sally Dougall, Timothy P Stinear, Julian Druce, Mike Catton, Brett Sutton, Annaliese van Diemen, Charles Alpren, Deborah A Williamson
Genomic sequencing has significant potential to inform public health management for SARS-CoV-2. Here we report high-throughput gen..
Clinical presentation of asymptomatic and symptomatic heterosexual men who tested positive for urethral gonorrhoea at a sexual health clinic in Melbourne, Australia
Mario Martin-Sanchez, Jason J Ong, Christopher K Fairley, Marcus Y Chen, Deborah A Williamson, Kate Maddaford, Ei T Aung, Georgia Carter, Catriona S Bradshaw, Eric PF Chow
BACKGROUND: Asymptomatic screening for gonorrhoea in heterosexual men is currently not recommended in many countries including Aus..
ANTISEPTIC MOUTHWASH FOR GONORRHOEA PREVENTION (OMEGA): A RANDOMISED, DOUBLE-BLIND, PARALLEL-GROUP, MULTICENTRE TRIAL
EPF Chow, DA Williamson, JS Hocking, MG Law, K Maddaford, CS Bradshaw, A McNulty, DJ Templeton, R Moore, GL Murray, JA Danielewski, R Wigan, MY Chen, RJ Guy, L Zhang, B Donovan, AE Grulich, JM Kaldor, DM Whiley, VJ Cornelisse
BACKGROUND: To address the increasing incidence of gonorrhoea and antimicrobial resistance, we compared the efficacy of Listerine ..
Validation of a single-step, single-tube reverse transcription loop-mediated isothermal amplification assay for rapid detection of SARS-CoV-2 RNA
Jean YH Lee, Nickala Best, Julie McAuley, Jessica L Porter, Torsten Seemann, Mark B Schultz, Michelle Sait, Nicole Orlando, Karolina Mercoulia, Susan A Ballard, Julian Druce, Thomas Tran, Mike G Catton, Melinda J Pryor, Huanhuan L Cui, Angela Luttick, Sean McDonald, Arran Greenhalgh, Jason C Kwong, Norelle L Sherry
Introduction. The SARS-CoV-2 pandemic of 2020 has resulted in unparalleled requirements for RNA extraction kits and enzymes requir..