OPTIMIZING THE EFFECTIVENESS AND DELIVERY OF STROKE REPERFUSION THERAPIES

Grant number: 1174514 | Funding period: 2020 - 2024

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Abstract

Stroke is a leading cause of death and disability in Australia and globally. Our previous work in the brain imaging and emergency treatment of stroke has transformed clinical practice globally, particularly in proving the benefits of mechanical clot retrieval and improved clot-dissolving medicine to reduce disability. Our planned research will optimise pre-hospital management of stroke to deliver time critical treatments earlier and undertake clinical trials to further improve patient outcomes.

Related publications (4)

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Sustained benefits for thrombectomy triage using the act-fast algorithm after real-world implementation

H Zhao, K Smith, D Anderson, M Stephenson, L Churilov, JL Ng, L Pesavento, L Weir, N Yassi, P Mitchell, S Davis, B Campbell

2022-10-01

Background and Aims: The severity-based ACT-FAST algorithm for pre-hospital triage of large vessel occlusion (LVO) has previously ..

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Early-phase dose articulation trials are underutilized for post-stroke motor recovery: A systematic scoping review

Emily J Dalton, Leonid Churilov, Natasha A Lannin, Dale Corbett, Bruce C Campbell, Kathryn S Hayward

2021-11-23

BACKGROUND: To enable development of effective interventions, there is a need to complete systematic early-phase dose articulation..

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Multidimensional Phase I Dose Ranging Trials for Stroke Recovery Interventions: Key Challenges and How to Address Them

Emily J Dalton, Leonid Churilov, Natasha A Lannin, Dale Corbett, Bruce C Campbell, Kathryn S Hayward

2021-06-04

Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajecto..

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Advancing Stroke Recovery Through Improved Articulation of Nonpharmacological Intervention Dose

Kathryn S Hayward, Leonid Churilov, Emily J Dalton, Amy Brodtmann, Bruce CV Campbell, David Copland, Numa Dancause, Erin Godecke, Tammy C Hoffmann, Natasha A Lannin, Matthew W McDonald, Dale Corbett, Julie Bernhardt

2021-02-01

Dose articulation is a universal issue of intervention development and testing. In stroke recovery, dose of a nonpharmaceutical in..

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