TARGETING THE VASCULAR MICROENVIRONMENT IN HUMAN DISEASE

Grant number: 1176732 | Funding period: 2020 - 2024

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Abstract

The focus of my research is to understand the role played by blood and lymphatic vessels in human diseases such as vascular disease, diabetes and cancer. While these vessels are vital for the growth, development and physiology of all animals, they can contribute through abnormalities in number, function or location to human pathologies. We will endeavour to understand the specific molecules which regulate the biological activity of these vessels, and use this information to develop therapeutics.

Related publications (5)

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Brain Vascular Microenvironments in Cancer Metastasis

Lucas E Tobar, Rae H Farnsworth, Steven A Stacker

2022-03-01

Primary tumours, particularly from major solid organs, are able to disseminate into the blood and lymphatic system and spread to d..

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Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death

Sylvain Garciaz, Andrew A Guirguis, Sebastian Muller, Fiona C Brown, Yih-Chih Chan, Ali Motazediani, Caitlin L Rowe, James A Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez

2022-03-01

UNLABELLED: Cancer cell metabolism is increasingly recognized as providing an exciting therapeutic opportunity. However, a drug th..

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Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

Tevin CY Chau, Sungmin Baek, Baptiste Coxam, Renae Skoczylas, Maria Rondon-Galeano, Neil I Bower, Elanor N Wainwright, Steven A Stacker, Helen M Cooper, Peter A Koopman, Anne K Lagendijk, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

2021-07-16

BACKGROUND: Lymphatic vascular development is regulated by well-characterized signaling and transcriptional pathways. These pathwa..

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Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Michael Y He, Michael M Halford, Ruofei Liu, James P Roy, Zoe L Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A Dawson, Marc G Achen, Steven A Stacker

2021-07-15

Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant an..

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Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis

Valeria Arcucci, Steven A Stacker, Marc G Achen

2021-02-01

Abstract: Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumo..