TARGETING THE VASCULAR MICROENVIRONMENT IN HUMAN DISEASE

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

Tevin CY Chau, Sungmin Baek, Baptiste Coxam, Renae Skoczylas, Maria Rondon-Galeano, Neil I Bower, Elanor N Wainwright, Steven A Stacker, Helen M Cooper, Peter A Koopman, Anne K Lagendijk, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

2021-07-16

BACKGROUND: Lymphatic vascular development is regulated by well-characterized signaling and transcriptional pathways. These pathwa..

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Michael Y He, Michael M Halford, Ruofei Liu, James P Roy, Zoe L Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A Dawson, Marc G Achen, Steven A Stacker

2021-07-15

Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant an..

Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis

Valeria Arcucci, Steven A Stacker, Marc G Achen

2021-02-01

Abstract: Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumo..