IMPROVING OUTCOMES IN SYSTEMIC AUTOIMMUNE DISEASE

Grant number: 1176538 | Funding period: 2020 - 2024

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Abstract

My research is focused on improving outcomes of autoimmune diseases scleroderma and lupus, that can affect multiple organs in the body, causing much morbidity and reduced life expectancy. My aim is to develop and apply new treatment strategies, working towards pre-defined goals, to ensure optimal quality of life, prevention of organ damage and maximised survival. My research entails international collaborations, working with consumers, and mentoring emergent researchers to address unmet needs.

Related publications (14)

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Disease specific determinants of cardiopulmonary fitness in systemic sclerosis

Laura Ross, Benedict Costello, Anniina Lindqvist, Dylan Hansen, Zoe Brown, Wendy Stevens, Andrew Burns, David Prior, Marcus Pianta, Warren Perera, Andre La Gerche, Mandana Nikpour

2023-02-01

OBJECTIVES: We aimed to quantify the burden of exercise intolerance in systemic sclerosis (SSc) and explore the disease features t..

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Impact of remission and low disease activity on health-related quality of life in patients with systemic lupus erythematosus.

Sharzad Emamikia, Shereen Oon, Alvaro Gomez, Julius Lindblom, Alexander Borg, Yvonne Enman, Eric Morand, David Grannas, Ronald F van Vollenhoven, Mandana Nikpour, Ioannis Parodis

2022-11-28

OBJECTIVES: To investigate the impact of remission and lupus low disease activity state (LLDAS) on health-related quality of life ..

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How toxic is an old friend? A review of the safety of hydroxychloroquine in clinical practice

Jessica L Fairley, Mandana Nikpour, Heather G Mack, Maria Brosnan, Amanda M Saracino, Marc Pellegrini, Ian P Wicks

2022-08-25

Hydroxychloroquine (HCQ) and its close relative chloroquine (CQ) were initially used as antimalarial agents but are now widely pre..

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Using magnetic resonance imaging to map the hidden burden of muscle involvement in systemic sclerosis

Laura Ross, Anniina Lindqvist, Benedict Costello, Dylan Hansen, Zoe Brown, Jessica A Day, Wendy Stevens, Andrew Burns, Warren Perera, Marcus Pianta, Andre La Gerche, Mandana Nikpour

2022-04-11

BACKGROUND: Skeletal muscle can be directly affected by systemic sclerosis (SSc); however, a significant burden of SSc-associated ..

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Myocardial fibrosis and arrhythmic burden in systemic sclerosis

Laura Ross, Benedict Costello, Zoe Brown, Dylan Hansen, Anniina Lindqvist, Wendy Stevens, Andrew Burns, David Prior, Mandana Nikpour, Andre La Gerche

2022-02-08

OBJECTIVES: Cardiac complications of SSc are a leading cause of SSc-associated death. Cardiac imaging for identifying substrate ab..

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Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes.

Aimee L Hanson, Joanne Sahhar, Gene-Siew Ngian, Janet Roddy, Jennifer Walker, Wendy Stevens, Mandana Nikpour, Shervin Assassi, Susanna Proudman, Maureen D Mayes, Tony J Kenna, Matthew A Brown

2022-01-08

Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The presence of detectable autoantibodie..

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The emerging association between bronchiectasis and systemic sclerosis: assessing prevalence and potential causality.

Rosemary Smith, Megan Harrison, Kay-Vin Lam, Brendan Adler, Max Bulsara, Joanne Sahhar, Wendy Stevens, Susanna Proudman, Mandana Nikpour, Eli Gabbay

2021-12-11

BACKGROUND: Bronchiectasis has been observed in association with systemic sclerosis (SSc). Theorised aetiology includes aspiration..

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Sudden Cardiac Death in Systemic Sclerosis: Diagnostics to Assess Risk and Inform Management

Laura Ross, Elizabeth Paratz, Murray Baron, Andre La Gerche, Mandana Nikpour

2021-10-01

Cardiac disease is a leading cause of death in systemic sclerosis (SSc) and sudden cardiac death (SCD) is thought to occur more co..

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Anti-Ro52/TRIM21 is independently associated with pulmonary arterial hypertension and mortality in a cohort of systemic sclerosis patients

AYS Lee, KA Patterson, DJ Tan, ME Wilson, SM Proudman, W Stevens, M Nikpour, J Sahhar, G-S Ngian, J Roddy, PJ Roberts-Thomson, JG Walker

2021-04-16

Objective: We undertook a comprehensive cross-sectional analysis of a multicentred Australian cohort of systemic sclerosis (SSc) p..

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Cost‐Effectiveness of Combination Therapy for Patients With Systemic Sclerosis–Related Pulmonary Arterial Hypertension

An Tran‐Duy, Kathleen Morrisroe, Philip Clarke, Wendy Stevens, Susanna Proudman, Joanne Sahhar, Mandana Nikpour

2021-04-06

Background: To evaluate the cost‐effectiveness of combination pulmonary arterial hypertension specific therapy in systemic scleros..

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Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus under long-term treatment with hydroxychloroquine'

Mandana Nikpour, Benjamin Teh, Ian P Wicks, Marc Pellegrini

2021-03-01

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Are troponin and B-type natriuretic peptides useful biomarkers for the diagnosis of systemic sclerosis heart involvement? A systematic literature review

Laura Ross, Jayne Moxey, Mandana Nikpour

2021-01-09

BACKGROUND: Systemic sclerosis (SSc) heart involvement (SHI) is a leading cause of SSc-associated mortality and once clinically ov..

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Controversies and advances in connective tissue disease-related pulmonary arterial hypertension

Kathleen Morrisroe, Mandana Nikpour

2020-10-01

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Damage Trajectories in Systemic Sclerosis Using Group-Based Trajectory Modeling

Ariane Barbacki, Murray Baron, Mianbo Wang, Yuqing Zhang, Mandana Nikpour, Ada Man

2020-10-01

OBJECTIVE: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive organ damage, which can be measured usin..

University of Melbourne Researchers