HARNESSING UNIVERSAL IMMUNITY TO INFLUENZA

Circulating effector gamma delta T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals

Anouk von Borstel, Thi HO Nguyen, Louise C Rowntree, Thomas M Ashhurst, Lilith F Allen, Lauren J Howson, Natasha E Holmes, Olivia C Smibert, Jason A Trubiano, Claire L Gordon, Allen C Cheng, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Martin S Davey

2023-02-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a smal..

Prospective comprehensive profiling of immune responses to COVID-19 vaccination in patients on zanubrutinib therapy.

Thi HO Nguyen, Chhay Lim, Masa Lasica, Ashley Whitechurch, Surekha Tennakoon, Natalie R Saunders, Lilith F Allen, Louise C Rowntree, Brendon Y Chua, Lukasz Kedzierski, Hyon-Xhi Tan, Adam K Wheatley, Stephen J Kent, Theo Karapanagiotidis, Suellen Nicholson, Deborah A Williamson, Monica A Slavin, Constantine S Tam, Katherine Kedzierska, Benjamin W Teh

2023-02-01

Zanubrutinib-treated and treatment-naïve patients with chronic lymphocytic leukaemia (CLL) or Waldenstrom's macroglobulinaemia wer..

T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance

Xin Gao, Kaiming Luo, Diya Wang, Yunbo Wei, Yin Yao, Jun Deng, Yang Yang, Qunxiong Zeng, Xiaoru Dong, Le Xiong, Dongcheng Gong, Lin Lin, Kai Pohl, Shaoling Liu, Yu Liu, Lu Liu, Thi HO Nguyen, Lilith F Allen, Katherine Kedzierska, Yanliang Jin

2023-01-19

A defining feature of successful vaccination is the ability to induce long-lived antigen-specific memory cells. T follicular helpe..

Identification of human progenitors of exhausted CD8 T cells associated with elevated IFN-γ response in early phase of viral infection.

Curtis Cai, Jerome Samir, Mehdi R Pirozyan, Thiruni N Adikari, Money Gupta, Preston Leung, Brendan Hughes, Willem Van der Byl, Simone Rizzetto, Auda Elthala, Elizabeth Keoshkerian, Jean-Louis Palgen, Timothy Peters, Thi HO Nguyen, Raymond Louie, Katherine Kedzierska, Silvana Gaudieri, Rowena A Bull, Andrew R Lloyd, Fabio Luciani

2022-12-07

T cell exhaustion is a hallmark of hepatitis C virus (HCV) infection and limits protective immunity in chronic viral infections an..

Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8( ) T Cells in the Face of Pre-Existing Humoral Immunity

Ming ZM Zheng, Svenja Fritzlar, Zhongfang Wang, Tiong Kit Tan, Katherine Kedzierska, Alain Townsend, Patrick C Reading, Linda M Wakim

2022-11-15

In this study, we investigated how pre-existing Ab immunity to influenza virus established from prior immunizations affects the de..

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi HO Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson

2022-10-01

Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their effi..

VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2

Mikhail Goncharov, Dmitry Bagaev, Dmitrii Shcherbinin, Ivan Zvyagin, Dmitry Bolotin, Paul G Thomas, Anastasia A Minervina, Mikhail V Pogorelyy, Kristin Ladell, James E McLaren, David A Price, Thi HO Nguyen, Louise C Rowntree, E Bridie Clemens, Katherine Kedzierska, Garry Dolton, Cristina Rafael Rius, Andrew Sewell, Jerome Samir, Fabio Luciani

2022-08-15

Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

Niels JM Verstegen, Ruth R Hagen, Jet van den Dijssel, Lisan H Kuijper, Christine Kreher, Thomas Ashhurst, Laura YL Kummer, Maurice Steenhuis, Mariel Duurland, Rivka de Jongh, Nina de Jong, C Ellen van der Schoot, Amelie Bos, Erik Mul, Katherine Kedzierska, Koos PJ van Dam, Eileen W Stalman, Laura Boekel, Gertjan Wolbink, Sander W Tas

2022-07-15

BACKGROUND: Patients affected by different types of autoimmune diseases, including common conditions such as multiple sclerosis (M..

SATB1 ensures appropriate transcriptional programs within naive CD8( ) T cells

Simone Nussing, Lisa A Miosge, Kah Lee, Moshe Olshansky, Adele Barugahare, Carla M Roots, Yovina Sontani, E Bridie Day, Marios Koutsakos, Katherine Kedzierska, Christopher C Goodnow, Brendan E Russ, Stephen R Daley, Stephen J Turner

2022-07-13

Special AT-binding protein 1 (SATB1) is a chromatin-binding protein that has been shown to be a key regulator of T-cell developmen..

SARS-CoV-2-specific T cell memory with common TCR alpha beta motifs is established in unvaccinated children who seroconvert after infection

Louise C Rowntree, Thi HO Nguyen, Lukasz Kedzierski, Melanie R Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F Allen, E Bridie Clemens, Brendon Chua, Hayley A McQuilten, Anastasia A Minervina, Mikhail Pogorelyy, Priyanka Chaurasia, Hyon-Xhi Tan, Adam K Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E Kaitlynn Allen, Sabrina Sonda

2022-07-12

As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains la..

Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain

Shidan Tosif, Ebene R Haycroft, Sohinee Sarkar, Zheng Quan Toh, Anh Ha Do Lien, Celeste M Donato, Kevin J Selva, Monsurul Hoq, Isabella Overmars, Jill Nguyen, Lai-Yang Lee, Vanessa Clifford, Andrew Daley, Francesa L Mordant, Jodie McVernon, Kim Mulholland, Adrian J Marcato, Miranda Z Smith, Nigel Curtis, Sarah McNab

2022-07-01

BACKGROUND: Household studies are crucial for understanding the transmission of SARS-CoV-2 infection, which may be underestimated ..

The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection

Huimeng Wang, Adam G Nelson, Bingjie Wang, Zhe Zhao, Xin Yi Lim, Mai Shi, Lucy J Meehan, Xiaoxiao Jia, Katherine Kedzierska, Bronwyn S Meehan, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Jeffrey YW Mak, David P Fairlie, James McCluskey, Zhongfang Wang, Alexandra J Corbett, Zhenjun Chen

2022-06-02

Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infec..

T Cell Epitope Discovery in the Context of Distinct and Unique Indigenous HLA Profiles

Luca Hensen, Patricia T Illing, Louise C Rowntree, Jane Davies, Adrian Miller, Steven YC Tong, Jennifer R Habel, Carolien E van de Sandt, Katie L Flanagan, Anthony W Purcell, Katherine Kedzierska, E Bridie Clemens

2022-05-06

CD8+ T cells are a pivotal part of the immune response to viruses, playing a key role in disease outcome and providing long-lastin..

Count on us: T cells in SARS-CoV-2 infection and vaccination

Katherine Kedzierska, Paul G Thomas

2022-03-15

Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pool..

Dual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation

Sara Suliman, Lars Kjer-Nielsen, Sarah K Iwany, Kattya Lopez Tamara, Liyen Loh, Ludivine Grzelak, Katherine Kedzierska, Tonatiuh A Ocampo, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Segundo R Leon, Roger Calderon, Leonid Lecca-Garcia, Megan B Murray, D Branch Moody, Ildiko Van Rhijn

2022-03-15

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT..

HLA-A*11:01-restricted CD8( ) T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people

Jennifer Habel, Andrea Nguyen, Louise Rowntree, Christopher Szeto, Nicole Mifsud, E Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane W Nelson, Jane Davies, Adrian Miller, Steven YCT Tong, Jamie Rossjohn, Stephanie M Gras, Anthony Purcell, Luca M Hensen, Katherine Kedzierska, Patricia M Illing

2022-03-01

HLA-A*11:01 is one of the most prevalent human leukocyte antigens (HLAs), especially in East Asian and Oceanian populations. It is..

Influenza virus infection history shapes antibody responses to influenza vaccination

Maria Auladell, Vu Mai Phuong Hoang, Thi Quynh Mai Le, Yeu-Yang Tseng, Louise Carolan, Sam Wilks, Quang Thai Pham, David Price, Thanh Duong Nguyen, Le Khang Hang Nguyen, Thi Thanh Le, Thi Hong Thuong Nguyen, Thi Kieu Huong Tran, Thi Ngoc Diep Nguyen, Thi Ngoc Bich Vu, Arseniy Khvorov, Luca Hensen, Nhu Duong Tran, Katherine Kedzierska, Duc Anh Dang

2022-02-17

Studies of successive vaccination suggest that immunological memory against past influenza viruses may limit responses to vaccines..

SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

Philip A Mudd, Anastasia A Minervina, Mikhail Pogorelyy, Jackson S Turner, Wooseob Kim, Elizaveta Kalaidina, Jan Petersen, Aaron J Schmitz, Tingting Lei, Alem Haile, Allison M Kirk, Robert C Mettelman, Jeremy Chase Crawford, Thi HO Nguyen, Louise C Rowntree, Elisa Rosati, Katherine A Richards, Andrea J Sant, Michael K Klebert, Teresa Suessen

2022-02-17

SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell responses. It is not yet clear whether vaccine-indu..

Are NKT cells a useful predictor of COVID-19 severity?

Hui-Fern Koay, Nicholas A Gherardin, Thi HO Nguyen, Wuji Zhang, Jennifer R Habel, Rebecca Seneviratna, Fiona James, Natasha E Holmes, Olivia C Smibert, Claire L Gordon, Jason A Trubiano, Katherine Kedzierska, Dale I Godfrey

2022-02-08

H7N9 bearing a mutation in the nucleoprotein leads to increased pathology in chickens.

Daniel S Layton, Jeffrey Butler, Cameron Stewart, Vicky Stevens, Jean Payne, Christina Rootes, Celine Deffrasnes, Som Walker, Songhua Shan, Tamara J Gough, Christopher Cowled, Kerri Bruce, Jianning Wang, Katherine Kedzierska, Frank YK Wong, Andrew GD Bean, John Bingham, David T Williams

2022-01-06

The zoonotic H7N9 avian influenza (AI) virus first emerged in 2013 as a low pathogenic (LPAI) strain, and has repeatedly caused hu..

Evaluation of Human Circulating T Follicular Helper Cells in Influenza- and SARS-CoV-2-Specific B Cell Immunity.

Marios Koutsakos, Katherine Kedzierska, Thi HO Nguyen

2022-01-01

Generation of effective immune protection against viral infection and vaccination depends greatly on a successful engagement and s..

T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants

Thi HO Nguyen, Carolyn A Cohen, Louise C Rowntree, Maireid B Bull, Asmaa Hachim, Katherine Kedzierska, Sophie A Valkenburg

2021-12-24

T cell responses are a key cornerstone to viral immunity to drive high-quality antibody responses, establishing memory for recall ..

A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2

Thomas S Fulford, Huy Van, Nicholas A Gherardin, Shuning Zheng, Marcin Ciula, Heidi E Drummer, Samuel Redmond, Hyon-Xhi Tan, Irene Boo, Rob J Center, Fan Li, Samantha L Grimley, Bruce D Wines, Thi HO Nguyen, Francesca L Mordant, Paula Ellenberg, Louise C Rowntree, Lukasz Kedzierski, Allen C Cheng, Denise L Doolan

2021-12-01

BACKGROUND: As vaccines against SARS-CoV-2 are now being rolled out, a better understanding of immunity to the virus, whether from..

Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians

Luca Hensen, Thi HO Nguyen, Louise C Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L Harland, Maria Auladell, Carolien E van de Sandt, Anngie Everitt, Cath Blacker, Damian A Oyong, Jessica R Loughland, Jessica R Webb, Bruce D Wines, P Mark Hogarth, Katie L Flanagan, Magdalena Plebanski, Adam Wheatley

2021-10-12

Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigen..

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Keith J Chappell, Francesca L Mordant, Zheyi Li, Danushka K Wijesundara, Paula Ellenberg, Julia A Lackenby, Stacey TM Cheung, Naphak Modhiran, Michael S Avumegah, Christina L Henderson, Kym Hoger, Paul Griffin, Jillian Bennet, Luca Hensen, Wuji Zhang, Thi HO Nguyen, Sara Marrero-Hernandez, Kevin J Selva, Amy W Chung, Mai H Tran

2021-09-22

BACKGROUND: Given the scale of the ongoing COVID-19 pandemic, the development of vaccines based on different platforms is essentia..

Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein

Priyanka Chaurasia, Thi HO Nguyen, Louise C Rowntree, Jennifer A Juno, Adam K Wheatley, Stephen J Kent, Katherine Kedzierska, Jamie Rossjohn, Jan Petersen

2021-09-01

CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-..

Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication

Claire L Gordon, Olivia C Smibert, Natasha E Holmes, Kyra YL Chua, Morgan Rose, George Drewett, Fiona James, Effie Mouhtouris, Thi HO Nguyen, Wuji Zhang, Lukasz Kedzierski, Louise C Rowntree, Brendon Y Chua, Leon Caly, Mike G Catton, Julian Druce, Michelle Sait, Torsten Seemann, Norelle L Sherry, Benjamin P Howden

2021-08-02

We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and ..

SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen

2021-06-30

In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells

Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki

2021-06-16

Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng

2021-05-18

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud

2021-05-11

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng

2021-05-11

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi

2021-04-01

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

2021-03-08

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Timon Damelang, Elizabeth H Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J Kent, Stephen J Rogerson, Amy W Chung

2021-02-18

Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can ind..

Genetic Bias, Diversity Indices, Physiochemical Properties and CDR3 Motifs Divide Auto-Reactive from Allo-Reactive T-Cell Repertoires

Oscar L Haigh, Emma J Grant, Thi HO Nguyen, Katherine Kedzierska, Matt A Field, John J Miles

2021-02-01

The distinct properties of allo-reactive T-cell repertoires are not well understood. To investigate whether auto-reactive and allo..

High expression of CD38 and MHC class II on CD8( ) T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Y Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshansky, William R Heath, So Young Chang, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska

2021-01-01

OBJECTIVES: Although co-expression of CD38 and HLA-DR reflects T-cell activation during viral infections, high and prolonged CD38+..

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

2021-01-01

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao

2021-01-01

OBJECTIVES: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, Sohinee Sarkar, Kevin J Selva, Anh Ha Do Lien, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Katie L Flanagan, Kelly B Arnold, Francesca L Mordant, Kim Mulholland, Julie Bines, Kate Dohle

2020-11-11

Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptom..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen

2020-09-29

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays

Marios Koutsakos, Toshiki Sekiya, Brendon Y Chua, Hoang Oanh Nguyen Thi, Adam K Wheatley, Jennifer A Juno, Marumi Ohno, Naoki Nomura, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Saori Suzuki, Hirohito Ishigaki, Misako Nakayama, Cong T Nguyen, Yasushi Itoh, Masashi Shingai, Kazumasa Ogasawara, Yoichiro Kino, Stephen J Kent

2020-09-07

Influenza remains a significant global public health burden, despite substantial annual vaccination efforts against circulating vi..

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

Irani Thevarajan, Thi HO Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven YC Tong, Sharon R Lewin, Katherine Kedzierska

2020-04-01