HARNESSING UNIVERSAL IMMUNITY TO INFLUENZA
Grant number: 1173871 | Funding period: 2020 - 2024
Related publications (21)
Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians.
Luca Hensen, Thi HO Nguyen, Louise C Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L Harland, Maria Auladell, Carolien E van de Sandt, Anngie Everitt, Cath Blacker, Damian A Oyong, Jessica R Loughland, Jessica R Webb, Bruce D Wines, P Mark Hogarth, Katie L Flanagan, Magdalena Plebanski, Adam Wheatley
Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigen..
Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial.
Keith J Chappell, Francesca L Mordant, Zheyi Li, Danushka K Wijesundara, Paula Ellenberg, Julia A Lackenby, Stacey TM Cheung, Naphak Modhiran, Michael S Avumegah, Christina L Henderson, Kym Hoger, Paul Griffin, Jillian Bennet, Luca Hensen, Wuji Zhang, Thi HO Nguyen, Sara Marrero-Hernandez, Kevin J Selva, Amy W Chung, Mai H Tran
BACKGROUND: Given the scale of the ongoing COVID-19 pandemic, the development of vaccines based on different platforms is essentia..
Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication.
Claire L Gordon, Olivia C Smibert, Natasha E Holmes, Kyra YL Chua, Morgan Rose, George Drewett, Fiona James, Effie Mouhtouris, Thi HO Nguyen, Wuji Zhang, Lukasz Kedzierski, Louise C Rowntree, Brendon Y Chua, Leon Caly, Mike G Catton, Julian Druce, Michelle Sait, Torsten Seemann, Norelle L Sherry, Benjamin P Howden
We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and ..
Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
Priyanka Chaurasia, Thi HO Nguyen, Louise C Rowntree, Jennifer A Juno, Adam K Wheatley, Stephen J Kent, Katherine Kedzierska, Jamie Rossjohn, Jan Petersen
CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-..
SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph
Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..
Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells
Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki
Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially..
CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph
Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng
Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..
CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients
Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng
How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..
TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs
Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua
The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..
Antibody mediated activation of natural killer cells in malaria exposed pregnant women
Timon Damelang, Elizabeth H Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J Kent, Stephen J Rogerson, Amy W Chung
Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can ind..
High expression of CD38 and MHC class II on CD8 T cells during severe influenza disease reflects bystander activation and trogocytosis
Xiaoxiao Jia, Brendon Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshanski, William Heath, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska
Although co-expression of CD38 and HLA-DR on CD8 + T cells reflects activation during influenza, SARS-CoV-2, Dengue, Ebola and HIV..
High expression of CD38 and MHC class II on CD8( ) T cells during severe influenza disease reflects bystander activation and trogocytosis
Xiaoxiao Jia, Brendon Y Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshansky, William R Heath, So Young Chang, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska
Objectives: Although co-expression of CD38 and HLA-DR reflects T-cell activation during viral infections, high and prolonged CD38+..
Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells
Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim
Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..
Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features
Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao
Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..
Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19
Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, Sohinee Sarkar, Kevin J Selva, Anh Ha Do Lien, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Katie L Flanagan, Kelly B Arnold, Francesca L Mordant, Kim Mulholland, Julie Bines, Kate Dohle
Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptom..
Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype
Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen
An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..
Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays
Marios Koutsakos, Toshiki Sekiya, Brendon Y Chua, Hoang Oanh Nguyen Thi, Adam K Wheatley, Jennifer A Juno, Marumi Ohno, Naoki Nomura, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Saori Suzuki, Hirohito Ishigaki, Misako Nakayama, Cong T Nguyen, Yasushi Itoh, Masashi Shingai, Kazumasa Ogasawara, Yoichiro Kino, Stephen J Kent
Influenza remains a significant global public health burden, despite substantial annual vaccination efforts against circulating vi..
Distinct systems serology features in children, elderly and COVID patients
Kevin Selva, Carolien van de Sandt, Melissa Lemke, Christina Lee, Suzanne Shoffner, Brendon Chua, Thi HO Nguyen, Louise Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, David Jackson, Katie Flanagan, Jane Crowe, Allen Cheng, Denise Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran
SARS-CoV-2, the pandemic coronavirus that causes COVID-19, has infected millions worldwide, causing unparalleled social and econom..
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
Irani Thevarajan, Thi HO Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven YC Tong, Sharon R Lewin, Katherine Kedzierska
Breadth of concomitant immune responses underpinning viral clearance and patient recovery in a non-severe case of COVID-19
Irani Thevarajan, Thi HO Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven YC Tong, Sharon Lewin, Katherine Kedzierska
We report the kinetics of the immune response in relation to clinical and virological features of a patient with mild-to-moderate ..