REFINING THE SYNAPTIC PRUNING HYPOTHESIS OF PSYCHOSIS IN HUMANS
Grant number: 1177370 | Funding period: 2020 - 2024
Schizophrenia is a distressing disorder for those that experience it. Despite over a century of research we are still not clear what biological and environmental factors impact the disorder. This research will investigate the role of specific components of the immune system and environmental factors in people with or at risk of schizophrenia and how they impact brain development and patient outcomes. This research will improve our understanding of the factors involved in schizophrenia.
Related publications (22)
Development of morning-eveningness in adolescence: implications for brain development and psychopathology
Rebecca Cooper, Maria A Di Biase, Bei Bei, Nicholas B Allen, Orli Schwartz, Sarah Whittle, Vanessa Cropley
BACKGROUND: Morning-evening preference is defined as an individual's preference for a morning- or evening-oriented rhythm. Across ..
In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia
Parsa Ravanfar, Warda T Syeda, Mahesh Jayaram, R Jarrett Rushmore, Bradford Moffat, Alexander P Lin, Amanda E Lyall, Antonia H Merritt, Negin Yaghmaie, Liliana Laskaris, Sandra Luza, Carlos M Opazo, Benny Liberg, M Mallar Chakravarty, Gabriel A Devenyi, Patricia Desmond, Vanessa L Cropley, Nikos Makris, Martha E Shenton, Ashley Bush
Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidat..
Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F Bartholomeusz, Michael WL Chee, Tiziano Colibazzi, Rebecca E Cooper, Cheryl M Corcoran, Vanessa L Cropley, Bjorn H Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. Howev..
Valuation system connectivity is correlated with poly-drug use in young adults
Kavinash Loganathan, Jinglei Lv, Vanessa Cropley, Andrew Zalesky, Eric Tatt Wei Ho
Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks m..
Characterization of facial emotion recognition in bipolar disorder: Focus on emotion mislabelling and neutral expressions
Lisa S Furlong, Susan L Rossell, James A Karantonis, Vanessa L Cropley, Matthew Hughes, Tamsyn E Van Rheenen
Increasing evidence suggests that facial emotion recognition is impaired in bipolar disorder (BD). However, patient-control differ..
Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness
Cassandra MJ Wannan, Cali F Bartholomeusz, Christos Pantelis, Maria A Di Biase, Warda T Syeda, M Mallar Chakravarty, Chad A Bousman, Ian P Everall, Patrick D McGorry, Andrew Zalesky, Vanessa L Cropley
Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between me..
Associations Between Neighborhood Disadvantage, Resting-State Functional Connectivity, and Behavior in the Adolescent Brain Cognitive Development Study: The Moderating Role of Positive Family and School Environments
Divyangana Rakesh, Caio Seguin, Andrew Zalesky, Vanessa Cropley, Sarah Whittle
BACKGROUND: Neighborhood disadvantage has consistently been associated with mental health and cognitive function, in addition to a..
Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..
Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence
Divyangana Rakesh, Vanessa Cropley, Andrew Zalesky, Nandita Vijayakumar, Nicholas B Allen, Sarah Whittle
Neighborhood disadvantage has consistently been linked to alterations in brain structure; however, positive environmental (e.g., p..
Functional Connectivity in Antipsychotic-Treated and Antipsychotic-Naive Patients With First-Episode Psychosis and Low Risk of Self-harm or Aggression A Secondary Analysis of a Randomized Clinical Trial
Sidhant Chopra, Shona M Francey, Brian O'Donoghue, Kristina Sabaroedin, Aurina Arnatkeviciute, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Christos Pantelis, Stephen J Wood, Patrick McGorry, Alex Fornito
IMPORTANCE: Altered functional connectivity (FC) is a common finding in resting-state functional magnetic resonance imaging (rs-fM..
Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder
Liliana Laskaris, Sam Mancuso, Cynthia Shannon Weickert, Andrew Zalesky, Gursharan Chana, Cassandra Wannan, Chad Bousman, Bernhard T Baune, Patrick McGorry, Christos Pantelis, Vanessa L Cropley
Deficits in brain morphology are one of the most widely replicated neuropathological features in schizophrenia-spectrum disorder (..
Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis An ENIGMA Working Group Mega-analysis
Maria Jalbrzikowski, Rebecca A Hayes, Stephen J Wood, Dorte Nordholm, Juan H Zhou, Paolo Fusar-Poli, Peter J Uhlhaas, Tsutomu Takahashi, Gisela Sugranyes, Yoo Bin Kwak, Daniel H Mathalon, Naoyuki Katagiri, Christine I Hooker, Lukasz Smigielski, Tiziano Colibazzi, Esther Via, Jinsong Tang, Shinsuke Koike, Paul E Rasser, Chantal Michel
IMPORTANCE: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at..
Brain-Predicted Age Associates With Psychopathology Dimensions in Youths
Vanessa L Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky
BACKGROUND: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of b..
Increased peripheral inflammation in schizophrenia is associated with worse cognitive performance and related cortical thickness reductions
Hayley F North, Jason Bruggemann, Vanessa Cropley, Vaidy Swaminathan, Suresh Sundram, Rhoshel Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Christos Pantelis, Thomas W Weickert, Cynthia Shannon Weickert
While the biological substrates of brain and behavioural changes in persons with schizophrenia remain unclear, increasing evidence..
Large-Scale Evidence for an Association Between Peripheral Inflammation and White Matter Free Water in Schizophrenia and Healthy Individuals
Maria A Di Biase, Andrew Zalesky, Suheyla Cetin-Karayumak, Yogesh Rathi, Jinglei Lv, Danny Boerrigter, Hayley North, Paul Tooney, Christos Pantelis, Ofer Pasternak, Cynthia Shannon Weickert, Vanessa L Cropley
INTRODUCTION: Clarifying the role of neuroinflammation in schizophrenia is subject to its detection in the living brain. Free-wate..
Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases
Parsa Ravanfar, Samantha M Loi, Warda T Syeda, Tamsyn E Van Rheenen, Ashley I Bush, Patricia Desmond, Vanessa L Cropley, Darius JR Lane, Carlos M Opazo, Bradford A Moffat, Dennis Velakoulis, Christos Pantelis
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new m..
The activity and connectivity of the facial emotion processing neural circuitry in bipolar disorder: a systematic review
Lisa S Furlong, Susan L Rossell, Georgia F Caruana, Vanessa L Cropley, Matthew Hughes, Tamsyn E Van Rheenen
BACKGROUND: Facial emotion processing abnormalities may be a trait feature of bipolar disorder (BD). These social cognitive impair..
The impact of smoking status on cognition and brain morphology in schizophrenia spectrum disorders
Elysha Ringin, Vanessa Cropley, Andrew Zalesky, Jason Bruggemann, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Chad A Bousman, Christos Pantelis, Tamsyn E Van Rheenen
BACKGROUND: Cigarette smoking is associated with worse cognition and decreased cortical volume and thickness in healthy cohorts. C..
Associations Between Delay Discounting and Connectivity of the Valuation-control System in Healthy Young Adults
Kavinash Loganathan, Jinglei Lv, Vanessa Cropley, Eric Tatt Wei Ho, Andrew Zalesky
The process of valuation assists in determining if an object or course of action is rewarding. Delay discounting is the observed d..
Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort
Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa L Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky
The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain ch..
Impaired olfactory ability associated with larger left hippocampus and rectus volumes at earliest stages of schizophrenia: A sign of neuroinflammation?
Yuri Masaoka, Dennis Velakoulis, Warrick J Brewer, Vanessa L Cropley, Cali F Bartholomeusz, Alison R Yung, Barnaby Nelson, Dominic Dwyer, Cassandra MJ Wannan, Masahiko Izumizaki, Patrick D McGorry, Stephen J Wood, Christos Pantelis
Impaired olfactory identification has been reported as a first sign of schizophrenia during the earliest stages of illness, includ..