Designing functional biomaterials with superior cellular interactions
Grant number: FT190100280 | Funding period: 2020 - 2024
This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffolds with a superior ability to promote the development of new tissue, and 2) create surfaces that will enable us to answer fundamental scientific questions regarding cell adhesion and cell/material interactions.
Related publications (2)
Amphiphilic Core Cross-Linked Star Polymers for the Delivery of Hydrophilic Drugs from Hydrophobic Matrices
Katarzyna Somszor, Stephanie Allison-Logan, Fatemeh Karimi, Thomas McKenzie, Qiang Fu, Andrea O'Connor, Greg Qiao, Daniel Heath
The delivery of hydrophilic drugs from hydrophobic polymers is a long-standing challenge in the biomaterials field due to the limi..
Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria
Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor
Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..