Does repeated influenza vaccination constrain influenza immune responses and protection? (NIH RO1 Sullivan Resubmission)
Grant number: 1R01AI141534-01 | Funding period: 2019 - 2024
PROJECT SUMMARY/ABSTRACT Over 140 million Americans are among the more than 500 million people who receive influenza vaccines an- nually. An important subgroup are healthcare workers (HCWs) for whom vaccination is recommended, and sometimes mandated, to protect themselves and vulnerable patients from influenza infection. However, there have been no large, long term studies of HCWs to support the effectiveness of these policies. HCWs are now a highly vaccinated population, the effects of which are also poorly understood. Mounting evidence suggests an- tibody responses to vaccination can be attenuated with repeated vaccination, which is corroborated by reports of poor vaccine effectiveness amo..View full description
Related publications (4)
Does repeated influenza vaccination attenuate effectiveness? A systematic review and meta-analysis
Elenor Jones-Gray, Elizabeth J Robinson, Adam J Kucharski, Annette Fox, Sheena G Sullivan
BACKGROUND: Influenza vaccines require annual readministration; however, several reports have suggested that repeated vaccination ..
Opposing Effects of Prior Infection versus Prior Vaccination on Vaccine Immunogenicity against Influenza A(H3N2) Viruses
Annette Fox, Louise Carolan, Vivian Leung, Vu Mai Phuong Hoang, Arseniy Khvorov, Maria Auladell, Yeu-Yang Tseng, Quang Thai Pham, Ian Barr, Kanta Subbarao, Thi Quynh Mai Le, H Rogier van Doorn, Sheena G Sullivan
Prior vaccination can alternately enhance or attenuate influenza vaccine immunogenicity and effectiveness. Analogously, we found t..
Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year After Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies
Christopher R Bailie, Yeu-Yang Tseng, Louise Carolan, Martyn D Kirk, Suellen Nicholson, Annette Fox, Sheena G Sullivan
A key aim of serosurveillance during the coronavirus disease 2019 (COVID-19) pandemic has been to estimate the prevalence of prior..