DEVELOPING NEW DIAGNOSTICS TO PREVENT STILLBIRTH

Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction.

Faith Andres, Natalie J Hannan, Susan P Walker, Teresa M MacDonald, Georgia P Wong, Ciara Murphy, Ping Cannon, Manju Kandel, Joshua Masci, Tuong-Vi Nguyen, Alison Abboud, Danica Idzes, Valerie Kyritsis, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2022-12-01

Placental dysfunction is the leading cause of both preeclampsia and fetal growth restriction. This study aimed to characterize end..

Circulating serine peptidase inhibitor Kunitz type 1 (SPINT1) in the second trimester is reduced among pregnancies that end in low birthweight neonates: cohort study of 2006 pregnancies.

Stephen Tong, Susan P Walker, Emerson Keenan, Teresa M MacDonald, Rennae Taylor, Lesley ME McCowan, Tu'uhevaha J Kaitu'u-Lino

2022-07-01

PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

Manju Kandel, Teresa M MacDonald, Susan P Walker, Catherine Cluver, Lina Bergman, Jenny Myers, Roxanne Hastie, Emerson Keenan, Natalie J Hannan, Ping Cannon, Tuong-Vi Nguyen, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2022-04-05

Background Preeclampsia is pregnancy specific, involving significant maternal endothelial dysfunction. Predictive biomarkers are l..

Circulating Activin A is elevated at 36 weeks' gestation preceding a diagnosis of preeclampsia

Georgia P Wong, Faith Andres, Susan P Walker, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Emerson Keenan, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2022-03-26

Activin A is aberrantly expressed by the preeclamptic placenta and circulating levels have been investigated as a potential biomar..

A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks' gestation in pregnancies destined to deliver small for gestational age infants

Faith Andres, Georgia P Wong, Susan P Walker, Teresa M MacDonald, Emerson Keenan, Ping Cannon, Tuong-Vi Nguyen, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2022-01-01

First trimester circulating ADAM12 is reduced in fetal growth restriction (FGR) and preeclampsia. We measured plasma ADAM12 at 36 ..

Circulating Growth Differentiation Factor 15 Is Increased Preceding Preeclampsia Diagnosis: Implications as a Disease Biomarker

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Emerson Keenan, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Jenny Myers, Catherine Cluver, Roxanne Hastie, Lina Bergman, Damanpreet Garcha, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Richard Hiscock, Natasha Pritchard, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2021-08-17

Background We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly ..

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Damanpreet Garcha, Susan P Walker, Teresa M MacDonald, Jon Hyett, Jessica Jellins, Jenny Myers, Sebastian E Illanes, Jhy K Nien, Manuel Schepeler, Emerson Keenan, Carole-Anne Whigham, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Manju Kandel, Joshua Masci, Ciara Murphy, Tess Cruickshank, Natasha Pritchard, Natalie J Hannan

2021-08-16

Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomar..

Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction

Ciara N Murphy, Susan P Walker, Teresa M MacDonald, Emerson Keenan, Natalie J Hannan, Mary E Wlodek, Jenny Myers, Jessica F Briffa, Tania Romano, Alexandra Roddy Mitchell, Carole-Anne Whigham, Ping Cannon, Tuong-Vi Nguyen, Manju Kandel, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2021-07-01

Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functi..

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Susan P Walker, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Suresh Anand Sadananthan, Mya-Thway Tint, Yi Ying Ong, Loy See Ling, Peter D Gluckman, Yap-Seng Chong, Keith M Godfrey, Shiao-Yng Chan, Kok Hian Tan, Yung Seng Lee, Navin Michael, Johan G Eriksson, Mary E Wlodek

2021-07-01

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low materna..

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia

Teresa M MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Nguyen Tuong-Vi, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Susan P Walker, Tu'uhevaha J Kaitu'u-Lino

2021-02-01

INTRODUCTION: Tissue Factor Pathway Inhibitor (TFPI) is a part of the extrinsic coagulation pathway, and highly expressed in the p..

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

2020-05-22

Background Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

2020-05-15

Purpose To investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-relate..