Liver Exosomes: Linking Non-Alcoholic Fatty Liver Disease and Insulin Resistance
Grant number: 1184309 | Funding period: 2020 - 2023
Completed
Abstract
Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes are common co-morbidities. Signals originating from the NAFLD liver negatively affect insulin sensitivity, but the underlying mechanisms remain unresolved. We will test whether the protein and lipid cargo of liver-derived exosomes is altered in NAFLD and whether exosomes derived from NAFLD livers cause insulin resistance and impaired glycemic control. This will be tested using human liver exosomes and studies in pre-clinical models.