MOLECULAR BASIS OF ZINC ACQUISITION BY STREPTOCOCCUS PNEUMONIAE

Grant number: 1180826 | Funding period: 2020 - 2022

Completed

Abstract

Streptococcus pneumoniae is the world’s foremost bacterial pathogen. In Australia, bacterial infections are responsible for more than 9000 deaths every year, and the economic burden associated with treating diseases arising from pneumococcal infections is more than $1 billion annually. This proposal aims to define the molecular basis of how bacteria scavenge zinc from the host environment. This knowledge will provide the foundation for next generation antimicrobial therapeutics.

Related publications (8)

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The role of CopA in Streptococcus pyogenes copper homeostasis and virulence.

Tina H Dao, Amy Iverson, Stephanie L Neville, Michael DL Johnson, Christopher A McDevitt, Jason W Rosch

2023-03-01

Maintenance of intracellular metal homeostasis during interaction with host niches is critical to the success of bacterial pathoge..

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Host-Mediated Copper Stress Is Not Protective against Streptococcus pneumoniae D39 Infection

Stephanie L Neville, Bliss A Cunningham, Eve A Maunders, Aimee Tan, Jacinta A Watts, Katherine Ganio, Bart A Eijkelkamp, Victoria G Pederick, Raquel Gonzalez de Vega, David Clases, Philip A Doble, Christopher A McDevitt

2022-11-22

Metal ions are required by all organisms for the chemical processes that support life. However, in excess they can also exert toxi..

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Structural and biochemical characterization of Acinetobacter baumannii ZnuA

Saleh Alquethamy, Katherine Ganio, Zhenyao Luo, Sheikh I Hossain, Andrew J Hayes, Thomas Ve, Mark R Davies, Evelyne Deplazes, Bostjan Kobe, Christopher A McDevitt

2022-06-01

Acinetobacter baumannii is a Gram-negative nosocomial pathogen associated with significant disease. Crucial to the survival and pa..

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The Impact of Chromate on Pseudomonas aeruginosa Molybdenum Homeostasis

Eve A Maunders, Dalton HY Ngu, Katherine Ganio, Sheikh I Hossain, Bryan YJ Lim, Michael G Leeming, Zhenyao Luo, Aimee Tan, Evelyne Deplazes, Bostjan Kobe, Christopher A McDevitt

2022-05-24

Acquisition of the trace-element molybdenum via the high-affinity ATP-binding cassette permease ModABC is essential for Pseudomona..

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MntP and YiiP Contribute to Manganese Efflux in Salmonella enterica Serovar Typhimurium under Conditions of Manganese Overload and Nitrosative Stress

Annie Ouyang, Kendall M Gasner, Stephanie L Neville, Christopher A McDevitt, Elaine R Frawley

2022-02-01

The divalent transition metal cation manganese is important for protein function, particularly under conditions of iron limitation..

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The Role of ZntA in Klebsiella pneumoniae Zinc Homeostasis

Eve A Maunders, Katherine Ganio, Andrew J Hayes, Stephanie L Neville, Mark R Davies, Richard A Strugnell, Christopher A McDevitt, Aimee Tan

2022-02-01

Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that is a leading cause of healthcare-associated infections, incl..

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Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake in Streptococcus pneumoniae

Marina L Zupan, Zhenyao Luo, Katherine Ganio, Victoria G Pederick, Stephanie L Neville, Evelyne Deplazes, Bostjan Kobe, Christopher A McDevitt

2021-08-19

Streptococcus pneumoniae scavenges essential zinc ions from the host during colonization and infection. This is achieved by the AT..

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Manganese import protects Salmonella enterica serovar Typhimurium against nitrosative stress

Shehla Yousuf, Joyce E Karlinsey, Stephanie L Neville, Christopher A McDevitt, Stephen J Libby, Ferric C Fang, Elaine R Frawley

2020-11-01

Nitric oxide (NO˙) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial..