RECOGNITION OF PHOSPHOANTIGEN BY GAMMA-DELTA T CELLS

Abstract

Understanding how the immune system recognizes foreign pathogens is important, and guides us in the development of new immune therapeutics for diseases such as cancer. This study aims to understand how a specialized subset of immune T cells, known as gamma-delta T cells, recognizes and responds to a highly novel class of foreign antigens, termed phosphoantigens. Our proposal will set the scene for development of novel forms of cancer immunotherapy.

Related publications (1)

Immune recognition of phosphoantigen-butyrophilin molecular complexes by gamma delta T cells

Adam P Uldrich, Marc Rigau, Dale I Godfrey

2020-10-05

Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhi..