ESTABLISHING THE FUNCTIONAL GENETIC DRIVERS OF OESOPHAGEAL ADENOCARCINOMA

Abstract

Survival from oesophageal cancer is low and current treatments are largely ineffective. Efforts to develop new therapies are hampered by a lack of understanding of what causes the cancer to develop at the molecular genetic level. This project will address this important issue by exploiting new genetic knowledge of the disease to comprehensively characterise the important molecular causes of oesophageal cancer and identify new targets for therapy.