RNA METHYLATION IN NORMAL AND MALIGNANT BLOOD DEVELOPMENT
Grant number: 1182804 | Funding period: 2020 - 2022
Sequencing studies that have compared the genomes and epigenomes of normal and malignant cells have revolutionised our understanding of cancer and have led to the development of new therapeutic strategies. Herein, we propose to study how the RNA modification m6A is regulated during physiological blood development and dysregulated in leukaemia.
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Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the noncoding genome and control..