Single Oligodendrocyte Genome Sequencing to Determine the Dynamics of Myelin Repair in Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is a brain disease that affects 25,000 Australians. In MS, the myelin sheath, which facilitates transmission of nerve impulses, gets damaged. This causes the symptoms of MS and can kill the cells that make myelin (oligodendrocytes) and the nerve cells, leading to untreatable progressive MS. Our project will study the DNA of oligodendrocytes to learn how these cells repair myelin because we believe that this could help to develop the first myelin repair medicines for MS.

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