STRUCTURAL CHARACTERISATION OF THE TYPE IX SECRETION SYSTEM

Grant number: DP200100914 | Funding period: 2020 - 2023

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Abstract

The Type IX Secretion System present in diverse bacteria of veterinary, agricultural, environmental and industrial importance enables effector proteins to be secreted and attached to the cell surface where they contribute to disease pathogenesis or degrade biopolymers of commercial interest. This project aims to determine the structure and assembly mechanism of this complex secretion nanomachine comprising 15 different proteins using state of the art microscopy. Knowledge of the structure will greatly enhance our understanding of secretion mechanisms and our ability to both inhibit the system to treat disease in animals or manipulate the system for industrial applications providing future ec..

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Related publications (4)

Protein interactome mapping of Porphyromonas gingivalis provides insights into the formation of the PorQ-Z complex of the type IX secretion system

Dhana G Gorasia, Paul D Veith, Eric C Reynolds

2022-08-03

Porphyromonas gingivalis is an anaerobic Gram-negative human oral pathogen highly associated with the more severe forms of periodo..

Type B CTD Proteins Secreted by the Type IX Secretion System Associate with PorP-like Proteins for Cell Surface Anchorage

Dhana G Gorasia, Christine A Seers, Jacqueline E Heath, Michelle D Glew, Hamid Soleimaninejad, Catherine A Butler, Mark J McBride, Paul D Veith, Eric C Reynolds

2022-05-01

The Bacteroidetes type IX secretion system (T9SS) consists of at least 20 components that translocate proteins with type A or type..

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Dhana G Gorasia, Ignacio Lunar Silva, Catherine A Butler, Maialene Chabalier, Thierry Doan, Eric Cascales, Paul D Veith, Eric C Reynolds

2022-02-01

The type IX secretion system (T9SS) transports cargo proteins through the outer membrane of Bacteroidetes and attaches them to the..

The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis

PD Veith, MD Glew, DG Gorasia, E Cascales, EC Reynolds

2021-12-10

Porphyromonas, Tannerella, and Prevotella species found in severe periodontitis use the Type IX Secretion System (T9SS) to load th..

University of Melbourne Researchers

Eric Reynolds Melbourne Dental School

Paul Veith Melbourne Dental School

Eric Hanssen Bio21 Institute