MODELLING HUMAN BRAIN DEVELOPMENT WITH STEM CELLS AND BIOMATERIALS

Grant number: DP200102870 | Funding period: 2021 - 2023

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Abstract

With limited resources to directly study and advance our understanding of human neural development, this proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neural networks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding of the human cortex. Further, biomaterials developed here have commercialisation potential, targeted at standardizing the culturing of..

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University of Melbourne Researchers

Clare Parish Florey Department of Neuroscience and Mental Health

David Nisbet Engineering and IT