Using single-cell genomics to resolve functional diversification by CD4+ T cells in vivo

Grant number: 1126399 | Funding period: 2020 - 2021



During immune responses, individual CD4+ T cells multiply and produce hundreds of descendants, with close relatives within a family often developing very different skills. How such differences emerge from one ancestor remains unclear. We use new methods to look at individual CD4+ T cells in unprecedented detail, allowing us to see how close relatives begin to grow apart. Using this, we hope to find novel ways of educating CD4+ T cells to prevent infectious and immune-mediated diseases.

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University of Melbourne Researchers