Using single-cell genomics to resolve functional diversification by CD4+ T cells in vivo
Grant number: 1126399 | Funding period: 2020 - 2021
Related publications (8)
Transcriptome dynamics of CD4( ) T cells during malaria maps gradual transit from effector to memory
Megan SF Soon, Hyun Jae Lee, Jessica A Engel, Jasmin Straube, Bryce S Thomas, Clara PS Pernold, Lachlan S Clarke, Pawat Laohamonthonkul, Rohit N Haldar, Cameron G Williams, Lianne IM Lansink, Marcela L Moreira, Michael Bramhall, Lambros T Koufariotis, Scott Wood, Xi Chen, Kylie R James, Tapio Lonnberg, Steven W Lane, Gabrielle T Belz
The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial che..
Single-cell transcriptomics of alloreactive CD4( ) T cells over time reveals divergent fates during gut graft-versus-host disease
Jessica A Engel, Hyun Jae Lee, Cameron G Williams, Rachel Kuns, Stuart Olver, Lianne IM Lansink, Megan SF Soon, Stacey B Andersen, Joseph E Powell, Valentine Svensson, Sarah A Teichmann, Geoffrey R Hill, Antiopi Varelias, Motoko Koyama, Ashraful Haque
Acute gastrointestinal (GI) graft-versus-host disease (GVHD) is a primary determinant of mortality after allogeneic hematopoietic ..
Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells
Jasmin Akter, David S Khoury, Rosemary Aogo, Lianne IM Lansink, Arya SheelaNair, Bryce S Thomas, Pawat Laohamonthonkul, Clara PS Pernold, Matthew WA Dixon, Megan SF Soon, Lily G Fogg, Jessica A Engel, Trish Elliott, Ismail Sebina, Kylie R James, Deborah Cromer, Miles P Davenport, Ashraful Haque
Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture..
Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice
Rosemary A Aogo, David S Khoury, Deborah Cromer, Trish Elliott, Jasmin Akter, Lily G Fogg, Arya Sheela Nair, Urijah N Liligeto, Megan SF Soon, Bryce S Thomas, Clara PS Pernold, Aleksandra S Romanczuk, Pawat Laohamonthonkul, Ashraful Haque, Miles P Davenport
A major mechanism of host-mediated control of blood-stage Plasmodium infection is thought to be removal of parasitized red blood c..
Within-host modeling of blood-stage malaria
David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport
Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..
A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications
Ashraful Haque, Jessica Engel, Sarah A Teichmann, Tapio Lonnberg
RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biologi..