HOW DO CD4+T CELLS PRESERVE MEMORIES?

Grant number: 1180951 | Funding period: 2020 - 2023

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Abstract

Memory is a defining feature of the immune system. The ability of CD4 T cells to retain information from one infection allows the body to act rapidly second time round. However, we know little about how CD4 T cells preserve memories, which prevents us improving this process in humans. We will use single-cell genomics and machine learning to determine how memory develops, functions and persists in CD4 T cells, to lay the foundation for improved vaccines against intractable infectious diseases.

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University of Melbourne Researchers

Ashraful Haque Microbiology and Immunology