HOW DO CD4+T CELLS PRESERVE MEMORIES?
Grant number: 1180951 | Funding period: 2020 - 2023
Memory is a defining feature of the immune system. The ability of CD4 T cells to retain information from one infection allows the body to act rapidly second time round. However, we know little about how CD4 T cells preserve memories, which prevents us improving this process in humans. We will use single-cell genomics and machine learning to determine how memory develops, functions and persists in CD4 T cells, to lay the foundation for improved vaccines against intractable infectious diseases.
Related publications (2)
Single-cell transcriptomics of alloreactive CD4( ) T cells over time reveals divergent fates during gut graft-versus-host disease
Jessica A Engel, Hyun Jae Lee, Cameron G Williams, Rachel Kuns, Stuart Olver, Lianne IM Lansink, Megan SF Soon, Stacey B Andersen, Joseph E Powell, Valentine Svensson, Sarah A Teichmann, Geoffrey R Hill, Antiopi Varelias, Motoko Koyama, Ashraful Haque
Acute gastrointestinal (GI) graft-versus-host disease (GVHD) is a primary determinant of mortality after allogeneic hematopoietic ..