Losing the needle: Using eye drop-based switchable gene therapy as a non-invasive controlled intervention in neovascular blindness

RNA-targeting strategies as a platform for ocular gene therapy.

Satheesh Kumar, Lewis E Fry, Jiang-Hui Wang, Keith R Martin, Alex W Hewitt, Fred K Chen, Guei-Sheung Liu

2023-01-01

Genetic medicine is offering hope as new therapies are emerging for many previously untreatable diseases. The eye is at the forefr..

Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization

Jiang-Hui Wang, Ching-Li Tseng, Fan-Li Lin, Jinying Chen, Erh-Hsuan Hsieh, Suraj Lama, Yu-Fan Chuang, Satheesh Kumar, Linxin Zhu, Myra B McGuinness, Jessika Hernandez, Leilei Tu, Peng-Yuan Wang, Guei-Sheung Liu

2022-01-01

Rationale: Corneal neovascularization (CoNV) is a severe complication of various types of corneal diseases, that leads to permanen..

Bulk Gene Expression Deconvolution Reveals Infiltration of M2 Macrophages in Retinal Neovascularization

Jiang-Hui Wang, Satheesh Kumar, Guei-Sheung Liu

2021-11-01

PURPOSE: This study interrogated the transcriptional features and immune cellular landscape of the retinae of rats subjected to ox..

TAK1 signaling is a potential therapeutic target for pathological angiogenesis

Linxin Zhu, Suraj Lama, Leilei Tu, Gregory J Dusting, Jiang-Hui Wang, Guei-Sheung Liu

2021-05-10

Angiogenesis plays a critical role in both physiological responses and disease pathogenesis. Excessive angiogenesis can promote ne..

A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization

Jinying Chen, Fan-Li Lin, Jacqueline YK Leung, Leilei Tu, Jiang-Hui Wang, Yu-Fan Chuang, Fan Li, Hsin-Hui Shen, Gregory J Dusting, Vickie HY Wong, Leszek Lisowski, Alex W Hewitt, Bang V Bui, Jingxiang Zhong, Guei-Sheung Liu

2020-09-15

Gene therapies that chronically suppress vascular endothelial growth factor (VEGF) represent a new approach for managing retinal v..