Identifying Novel Therapeutic Targets in Leukaemia Stem Cells

Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia

SJV Gordon, F Perner, L Macpherson, KA Fennell, DV Wenge, W Bourgeois, T Klaus, T Plenge, A Murat, J Petrovic, J Horvath, JQ Cao, JD Lapek, S Uryu, JR White, EYN Lam, XJ Mu, YC Chan, A Gillespie, BJ Blyth

2025-10-01

Targeting MYST acetyltransferases is an exciting therapeutic opportunity in acute myeloid leukemia (AML). In this study, we define..