Understanding immune responses to severe influenza virus infection and vaccination in humans
Grant number: 1194036 | Funding period: 2021 - 2025
Related publications (7)
Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication.
Claire L Gordon, Olivia C Smibert, Natasha E Holmes, Kyra YL Chua, Morgan Rose, George Drewett, Fiona James, Effie Mouhtouris, Thi HO Nguyen, Wuji Zhang, Lukasz Kedzierski, Louise C Rowntree, Brendon Y Chua, Leon Caly, Mike G Catton, Julian Druce, Michelle Sait, Torsten Seemann, Norelle L Sherry, Benjamin P Howden
We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and ..
Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
Priyanka Chaurasia, Thi HO Nguyen, Louise C Rowntree, Jennifer A Juno, Adam K Wheatley, Stephen J Kent, Katherine Kedzierska, Jamie Rossjohn, Jan Petersen
CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-..
SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph
Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..
CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients
Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng
How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..
Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells
Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim
Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..
Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features
Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao
Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..