Understanding immune responses to severe influenza virus infection and vaccination in humans

CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud

2021-05-11

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients.

Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nüssing, Xiaoxiao Jia, Patrick Günther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng

2021-05-11

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

2021-01-01

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao

2021-01-01

Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..