Better evidence and new tools to improve health after surgical menopause

Grant number: 1193838 | Funding period: 2021 - 2026

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Abstract

Surgical menopause is removal of both ovaries before natural menopause. Surgical menopause may have severe adverse health consequences including short-term symptoms and long-term risk of chronic disease, but more information is needed to inform evidence-based care. This study will deliver the best available evidence internationally on the short (up to 5 year) and long (>20 year) consequences of surgical menopause and new tools for clinicians and patients to integrate this evidence into practice

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OBJECTIVE: Understanding how symptoms cluster after premenopausal risk-reducing salpingo-oophorectomy (RRSO) can inform patient ex..

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Menopause, hysterectomy, menopausal hormone therapy and cause-specific mortality: cohort study of UK Biobank participants

Zhiwei Xu, Hsin-Fang Chung, Annette J Dobson, Louise F Wilson, Martha Hickey, Gita D Mishra

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Birthweight, gestational age and familial confounding in sex differences in infant mortality: a matched co-twin control study of Brazilian male-female twin pairs identified by population data linkage

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BACKGROUND: In infancy, males are at higher risk of dying than females. Birthweight and gestational age are potential confounders ..

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The incidence of many hormone-dependent diseases, including testicular cancer, has sharply increased in all high-income countries ..

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Bilateral oophorectomy and rate of colorectal cancer: A prospective cohort study

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Worldwide, colorectal cancer is the second most common cancer and third cause of cancer death in women. Estrogen exposure has been..

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Sex-dependent associations between maternal prenatal stressful life events, BMI trajectories and obesity risk in offspring: The Raine Study.

Elvira V Bräuner, Youn-Hee Lim, Trine Koch, Trevor A Mori, Lawrence Beilin, Dorota A Doherty, Anders Juul, Roger Hart, Martha Hickey

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BACKGROUND: There is a high and growing prevalence of childhood obesity which increases the risk of adult obesity and adverse phys..