Targeting vitamin-reactive T cells for enhanced immunity
Grant number: 1193745 | Funding period: 2021 - 2025
A specialised set of T cells called mucosal-associated invariant T (MAIT) cells react against bacteria and yeast, and reside at mucosal sites where the body's immune defences are often breached, e.g. respiratory tract and intestinal mucosa. This study seeks to define the molecular signals driving the function of MAIT cells, particularly during infections. This information may lead to methods tailored to manipulating MAIT cells therapeutically.
Related publications (6)
RIPK3 controls MAIT cell accumulation during development but not during infection
Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G Nelson, Bronte Ennis, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M Lew, Daniel G Pellicci, James McCluskey, Yifan Zhan
Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell de..
T-cell receptor αβ double-negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia-reperfusion injury.
Sarah L Snelgrove, Olivia Susanto, Louisa Yeung, Pamela Hall, M Ursula Norman, Alexandra J Corbett, A Richard Kitching, Michael J Hickey
T-cell receptor+ CD4- CD8- double-negative (DN) T cells are a population of T cells present in low abundance in blood and lymphoid..
Human mucosal V alpha 7.2( )CD161(hi) T cell distribution at physiologic state and in Helicobacter pylori infection
Norasate Boonpattanaporn, Thidarat Kongkaew, Panjana Sengprasert, Michael NT Souter, Narisorn Lakananurak, Rungsun Rerknimitr, Alexandra J Corbett, Rangsima Reantragoon
Mucosal-associated invariant T (MAIT) cells are innate-like, unconventional T cells that are present in peripheral blood and mucos..
The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection
Huimeng Wang, Adam G Nelson, Bingjie Wang, Zhe Zhao, Xin Yi Lim, Mai Shi, Lucy J Meehan, Xiaoxiao Jia, Katherine Kedzierska, Bronwyn S Meehan, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Jeffrey YW Mak, David P Fairlie, James McCluskey, Zhongfang Wang, Alexandra J Corbett, Zhenjun Chen
Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infec..
Dual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation
Sara Suliman, Lars Kjer-Nielsen, Sarah K Iwany, Kattya Lopez Tamara, Liyen Loh, Ludivine Grzelak, Katherine Kedzierska, Tonatiuh A Ocampo, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Segundo R Leon, Roger Calderon, Leonid Lecca-Garcia, Megan B Murray, D Branch Moody, Ildiko Van Rhijn
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT..
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey YW Mak, Sidonia BG Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey
Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cell..