The Hippo pathway in development and cancer

Grant number: 1194467 | Funding period: 2021 - 2025

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Abstract

Appropriate growth of organs is essential for life and can go awry in diseases such as cancer. A crucial regulator of organ size and cancer that I co-discovered is the Hippo pathway. I aim to understand how this pathway relays information and controls gene expression to regulate organ size, and its role in mesothelioma and other human cancers. A better understanding of Hippo’s role in organ growth and cancer will allow it to be targeted for therapeutic benefit in human diseases.

Related publications (4)

NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development

Joshua Hudson, Sayantanee Paul, Alexey Veraksa, Amin Ghabrial, Kieran F Harvey, Carole Poon

2023-01-19

The Germinal Center Kinase III (GckIII) pathway is a Hippo-like kinase module defined by sequential activation of Ste20 kinases Th..

TAZ/YAP fusion proteins: mechanistic insights and therapeutic opportunities.

Keith Garcia, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas

2022-12-01

The Hippo pathway is dysregulated in many different cancers, but point mutations in the pathway are rare. Transcriptional co-activ..

The Hippo pathway uses different machinery to control cell fate and organ size

Jonathan M Pojer, Samuel A Manning, Benjamin Kroeger, Shu Kondo, Kieran F Harvey

2021-08-20

The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that ..

Crumbs and the apical spectrin cytoskeleton regulate r8 cell fate in the Drosophila eye

Jonathan M Pojer, Abdul Jabbar Saiful Hilmi, Shu Kondo, Kieran F Harvey

2021-06-01

The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanog..

University of Melbourne Researchers

Kieran Harvey The Sir Peter Maccallum Department of Oncology