The Hippo Pathway in Development and Cancer

Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription

B Kroeger, SA Manning, V Mohan, J Lou, G Sun, S Lamont, AJ McCann, M Francois, JM Polo, E Hinde, KF Harvey

2025-07-25

Over the past two decades, genetic and proteomic screens have identified the Hippo pathway as a complex signaling network that con..

Damsel: analysis and visualisation of DamID sequencing in R

CG Page, A Londsdale, KA Mitchell, J Schröder, KF Harvey, A Oshlack

2024-12-01

DamID sequencing is a technique to map the genome-wide interaction of a protein with DNA. Damsel is the first Bioconductor package..

Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture

J Lou, Q Deng, X Zhang, CC Bell, AB Das, NG Bediaga, CO Zlatic, TM Johanson, RS Allan, MDW Griffin, PN Paradkar, KF Harvey, MA Dawson, E Hinde

2024-10-14

Our understanding of heterochromatin nanostructure and its capacity to mediate gene silencing in a living cell has been prevented ..

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

A Kulkarni, V Mohan, TT Tang, L Post, YC Chan, M Manning, N Thio, BL Parker, MA Dawson, J Rosenbluh, JHA Vissers, KF Harvey

2024-09-10

The Hippo tumor suppressor pathway controls transcription by regulating nuclear abundance of YAP and TAZ, which activate transcrip..

The JNK and Hippo pathways control epithelial integrity and prevent tumor initiation by regulating an overlapping transcriptome

Katrina A Mitchell, Joseph HA Vissers, Jonathan M Pojer, Elliot Brooks, Abdul Jabbar Saiful Hilmi, Anthony T Papenfuss, Jan Schroder, Kieran F Harvey

2024-09-09

Epithelial organs maintain their integrity and prevent tumor initiation by actively removing defective cells, such as those that h..

The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other's chromatin binding dynamics and transcription in vivo

SA Manning, B Kroeger, Q Deng, E Brooks, Y Fonseka, E Hinde, KF Harvey

2024-07-08

The Hippo pathway is an important regulator of organ growth and cell fate. The major mechanism by which Hippo is known to control ..

Vasculature is getting Hip(po): Hippo signaling in vascular development and disease

S Kobayashi, AG Cox, KF Harvey, BM Hogan

2023-12-04

The Hippo signaling pathway regulates developmental organ growth, regeneration, and cell fate decisions. Although the role of the ..

Dedifferentiation-derived neural stem cells exhibit perturbed temporal progression

K Veen, PK Nguyen, F Froldi, Q Dong, E Alvarez-Ochoa, KF Harvey, JPD McMullen, O Marshall, PR Jusuf, LY Cheng

2023-06-05

Dedifferentiation is the reversion of mature cells to a stem cell-like fate, whereby gene expression programs are altered and gene..

NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development

J Hudson, S Paul, A Veraksa, A Ghabrial, KF Harvey, C Poon

2023-03-01

The Germinal Center Kinase III (GckIII) pathway is a Hippo-like kinase module defined by sequential activation of Ste20 kinases Th..

TAZ/YAP fusion proteins: mechanistic insights and therapeutic opportunities

K Garcia, AC Gingras, KF Harvey, MR Tanas

2022-12-01

The Hippo pathway is dysregulated in many different cancers, but point mutations in the pathway are rare. Transcriptional co-activ..