The Hippo pathway in development and cancer
Grant number: 1194467 | Funding period: 2021 - 2025
Appropriate growth of organs is essential for life and can go awry in diseases such as cancer. A crucial regulator of organ size and cancer that I co-discovered is the Hippo pathway. I aim to understand how this pathway relays information and controls gene expression to regulate organ size, and its role in mesothelioma and other human cancers. A better understanding of Hippo’s role in organ growth and cancer will allow it to be targeted for therapeutic benefit in human diseases.
Related publications (2)
The Hippo pathway uses different machinery to control cell fate and organ size
Jonathan M Pojer, Samuel A Manning, Benjamin Kroeger, Shu Kondo, Kieran F Harvey
The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that ..
Crumbs and the apical spectrin cytoskeleton regulate r8 cell fate in the Drosophila eye
Jonathan M Pojer, Abdul Jabbar Saiful Hilmi, Shu Kondo, Kieran F Harvey
The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanog..