Evaluation of new biomarkers of coagulation in high risk cardiovascular population

Grant number: 1151535 | Funding period: 2020 - 2021

Completed

Abstract

Predicting the cardiovascular risk of an individual remains challenging despite the current advances and to date, there is no available laboratory testing that accurately reflects an individual’s clotting profile. This prospective study aims to address this with the use of global coagulation assay as a novel tool for individual cardiovascular risk prognostication and management, as well as demonstrate the compensatory mechanism between the different arms of Virchow's triad.

Related publications (6)

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The evaluation of overall hemostatic potential assay in patients with COVID-19 infection

Niki Lee, Julie Wang, Rowena Brook, Paul Monagle, Geoffrey Donnan, Harshal Nandurkar, Prahlad Ho, Hui Yin Lim

2022-05-27

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Global coagulation assays in hypercoagulable states

Hui Yin Lim, Geoffrey Donnan, Harshal Nandurkar, Prahlad Ho

2022-01-08

Thrombosis is one of the major global causes of morbidity and mortality, and predicting the risk of thrombotic and cardiovascular ..

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Global coagulation assays - Proposed reference intervals for healthy controls

Hui Yin Lim, Kay Weng Choy, Julie Wang, Harshal Nandurkar, Prahlad Ho

2021-10-27

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Global coagulation assays in patients with diabetes mellitus

Hui Yin Lim, Brandon Lui, Mark Tacey, Anna Kwok, Suresh Varadarajan, Geoffrey Donnan, Harshal Nandurkar, Prahlad Ho

2021-10-01

BACKGROUND: There is significant heterogeneity in the incidence and severity of diabetes-associated vascular complications and the..

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Global coagulation assays in healthy controls: are there compensatory mechanisms within the coagulation system?

Hui Yin Lim, Brandon Lui, Mark Tacey, Carly Selan, Geoffrey Donnan, Louise M Burrell, Harshal Nandurkar, Prahlad Ho

2021-02-24

Global coagulation assays (GCAs) may provide a more comprehensive individual hemostatic profiling. We aim to evaluate GCAs (thromb..

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Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy

Hui Yin Lim, Shalem Y Leemaqz, Niloufar Torkamani, Mathis Grossmann, Jeffrey D Zajac, Harshal Nandurkar, Prahlad Ho, Ada S Cheung

2020-07-01

Context The thrombotic effects of estradiol therapy in transgender women are unclear. Global coagulation assays (GCA) may be bette..