Investigating the basis of MAIT cell antigen potency (NIH R01 Resubmission)

Grant number: 1R01AI148407-01A1 | Funding period: 2020 - 2025



SUMMARY Mucosal Associated Invariant T (MAIT) cells comprise up to 10% of human peripheral blood T cells, and are enriched in the liver, lungs and gastrointestinal mucosa. This indicates that MAIT cells are key players in immunity. However, their roles in immune protection, and in immunopathology are yet to be fully established. Nevertheless, MAIT cells are implicated in chronic inflammatory diseases including tuberculosis, peptic ulceration, periodontal disease and inflammatory bowel disease. Central to the function of MAIT cells is the MAIT T cell antigen receptor (TCR). Consistent with their innate-like phenotype, MAIT cells express a very restricted T cell repertoire. Namely, human MAIT ..

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