Investigating the basis of MAIT cell antigen potency (NIH R01 Resubmission)

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

Caroline L Ashley, Brian P McSharry, Hamish EG McWilliam, Richard J Stanton, Ceri A Fielding, Rommel A Mathias, David P Fairlie, James McCluskey, Jose A Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman

2023-02-10

INTRODUCTION: The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to presen..

Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I-related protein 1 MR1

Carl JH Wang, Wael Awad, Ligong Liu, Jeffrey YW Mak, Natacha Veerapen, Patricia T Illing, Anthony W Purcell, Sidonia BG Eckle, James McCluskey, Gurdyal S Besra, David P Fairlie, Jamie Rossjohn, Jerome Le Nours

2022-12-01

The Major Histocompatibility Complex class I-related protein 1 (MR1) presents small molecule metabolites, drugs, and drug-like mol..

A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells

Hui Jing Lim, Jacinta M Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey YW Mak, Abderrahman Hachani, Regan J Anderson, Gavin F Painter, Jesse Goyette, Shanika L Amarasinghe, Matthew E Ritchie, Antoine Roquilly, David P Fairlie, Katharina Gaus, Jamie Rossjohn, Jose A Villadangos, Hamish EG McWilliam

2022-09-21

MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B-related metabolite antigens from div..

Human mucosal V alpha 7.2( )CD161(hi) T cell distribution at physiologic state and in Helicobacter pylori infection

Norasate Boonpattanaporn, Thidarat Kongkaew, Panjana Sengprasert, Michael NT Souter, Narisorn Lakananurak, Rungsun Rerknimitr, Alexandra J Corbett, Rangsima Reantragoon

2022-06-15

Mucosal-associated invariant T (MAIT) cells are innate-like, unconventional T cells that are present in peripheral blood and mucos..

The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection

Huimeng Wang, Adam G Nelson, Bingjie Wang, Zhe Zhao, Xin Yi Lim, Mai Shi, Lucy J Meehan, Xiaoxiao Jia, Katherine Kedzierska, Bronwyn S Meehan, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Jeffrey YW Mak, David P Fairlie, James McCluskey, Zhongfang Wang, Alexandra J Corbett, Zhenjun Chen

2022-06-02

Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infec..

Unlocking autofluorescence in the era of full spectrum analysis: Implications for immunophenotype discovery projects

Vanta J Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K Mackay, Axel Kallies, Jose A Villadangos, Hamish EG McWilliam, Alexis Perez-Gonzalez

2022-04-12

Understanding the complex elements affecting signal resolution in cytometry is key for quality experimental design and data. In th..

Dual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation

Sara Suliman, Lars Kjer-Nielsen, Sarah K Iwany, Kattya Lopez Tamara, Liyen Loh, Ludivine Grzelak, Katherine Kedzierska, Tonatiuh A Ocampo, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Segundo R Leon, Roger Calderon, Leonid Lecca-Garcia, Megan B Murray, D Branch Moody, Ildiko Van Rhijn

2022-03-15

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT..

Differential antigen requirements by diverse MR1-restricted T cells (vol 100, pg 112, 2022)

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

2022-02-15

Correction to: Immunol Cell Biol 2022; 100: 112–126; https://doi.org/10.1111/imcb.12519 The authors omitted a grant from the Natio..

Differential antigenic requirements by diverse MR1-restricted T cells

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

2022-01-13

MHC-related protein 1 (MR1) presents microbial riboflavin metabolites to mucosal-associated invariant T (MAIT) cells for surveilla..

Recognition of the antigen-presenting molecule MR1 by a Vd(3 ) delta d T cell receptor

Michael T Rice, Anouk von Borstel, Priyanka Chevour, Wael Awad, Lauren J Howson, Dene R Littler, Nicholas A Gherardin, Jerome Le Nours, Edward M Giles, Richard Berry, Dale Godfrey, Martin S Davey, Jamie Rossjohn, Benjamin S Gully

2021-12-07

Unlike conventional αβ T cells, γδ T cells typically recognize nonpeptide ligands independently of major histocompatibility comple..

Varicella Zoster Virus Impairs Expression of the Nonclassical Major Histocompatibility Complex Class I-Related Gene Protein (MR1)

Shivam K Purohit, Carolyn Samer, Hamish EG McWilliam, Renee Traves, Megan Steain, Brian P McSharry, Paul R Kinchington, David C Tscharke, Jose A Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman

2021-11-24

The antigen presentation molecule MR1 (major histocompatibility complex, class I-related) presents ligands derived from the ribofl..

Regulation of dendritic cell function by Fc-gamma-receptors and the neonatal Fc receptor

Christophe Macri, Huw Morgan, Jose A Villadangos, Justine D Mintern

2021-09-23

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among ..

Our evolving understanding of the role of the gamma delta T cell receptor in gamma delta T cell mediated immunity

Benjamin S Lully, Jamie Rossjohn, Martin S Davey

2021-09-13

The γδ T cell immune cell lineage has remained relatively enigmatic and under-characterised since their identification. Conversely..

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey YW Mak, Sidonia BG Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey

2021-07-16

Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cell..

Mouse models illuminate MAIT cell biology

Huimeng Wang, Zhenjun Chen, James McCluskey, Alexandra J Corbett

2021-02-01

The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based ..

When it's good to have MAITs

Michael NT Souter, James McCluskey, Alexandra J Corbett

2020-10-11

This article discusses mucosal-associated invariant T-cell prophylactic and therapeutic vaccination schemes tested by Sakai et al...