The genetic causes of male infertility
Grant number: 1120356 | Funding period: 2020 - 2021
Related publications (6)
A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships.
Brendan J Houston, Antoni Riera-Escamilla, Margot J Wyrwoll, Albert Salas-Huetos, Miguel J Xavier, Liina Nagirnaja, Corinna Friedrich, Don F Conrad, Kenneth I Aston, Csilla Krausz, Frank Tüttelmann, Moira K O'Bryan, Joris A Veltman, Manon S Oud
BACKGROUND: Human male infertility has a notable genetic component, including well-established diagnoses such as Klinefelter syndr..
Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility
Chunyu Liu, Chaofeng Tu, Lingbo Wang, Huan Wu, Brendan J Houston, Francesco K Mastrorosa, Wen Zhang, Ying Shen, Jiaxiong Wang, Shixiong Tian, Lanlan Meng, Jiangshan Cong, Shenmin Yang, Yiwen Jiang, Shuyan Tang, Yuyan Zeng, Mingrong Lv, Ge Lin, Jinsong Li, Hexige Saiyin
Asthenoteratozoospermia characterized by multiple morphological abnormalities of the flagella (MMAF) has been identified as a sub-..
The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse
Brendan J Houston, Liina Nagirnaja, D Jo Merriner, Anne E O'Connor, Hidenobu Okuda, Kenan Omurtag, Craig Smith, Kenneth I Aston, Donald F Conrad, Moira K O'Bryan
BACKGROUND: Male infertility is a prevalent clinical presentation for which there is likely a strong genetic component due to the ..
Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development
Brendan J Houston, Manon S Oud, Daniel M Aguirre, D Jo Merriner, Anne E O'Connor, Ozlem Okutman, Stephane Viville, Richard Burke, Joris A Veltman, Moira K O'Bryan
Globozoospermia is a rare form of male infertility where men produce round-headed sperm that are incapable of fertilizing an oocyt..
Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia
MS Oud, O Okutman, LAJ Hendricks, PF de Vries, BJ Houston, LELM Vissers, MK O'Bryan, L Ramos, HE Chemes, S Viville, JA Veltman
STUDY QUESTION: Can exome sequencing identify new genetic causes of globozoospermia? SUMMARY ANSWER: Exome sequencing in 15 cases ..