Molecular studies of dentine phosphophoryn and development of a biomimetic dental restorative material.
Grant number: 251707
This project involves the study of a protein that is found in teeth and is responsible for the development of dentine. The project involves characterisation of this protein and its interaction with calcium phosphate mineral using a variety of techniques. The information obtained will allow the synthesis of a peptide that will mimick the function of phosphophoryn. This peptide will be used together with stabilized amorphous calcium phosphate in a novel dental restorative material that will help protect the surrounding tooth tissue.The outcome will be an improved understanding of the design principles used by nature to engineer teeth. The significance is the potential development of biocompati..View full description
Related publications (2)
Synthesis and characterisation of a multiphosphorylated phosphophoryn repeat motif; H-[Asp-(Ser(P))(2)](3)-Asp-OH
Neil M O'Brien-Simpson, Troy J Attard, Ashwini Loganathan, N Laila Huq, Keith J Cross, Peter F Riley, Eric C Reynolds
Protein phosphorylation is a critical mechanism in the regulation of cellular biochemical pathways and phosphopeptides can play an..